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Article

Association of Calcitriol Supplementation with Reduced COVID-19 Mortality in Patients with Chronic Kidney Disease: A Population-Based Study

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Internal Medicine Service, Parc Taulí Health Corporation Consortium, 08208 Sabadell, Catalonia, Spain
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Parc Taulí Research and Innovation Institute (I3PT), 08208 Sabadell, Catalonia, Spain
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Department of Medicine, Autonomous University of Barcelona, 08193 Barcelona, Catalonia, Spain
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Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 08003 Barcelona, Catalonia, Spain
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Hospital del Mar Medical Research Institute (IMIM), 08003 Barcelona, Catalonia, Spain
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Rheumatology Service, Parc Taulí Health Corporation Consortium, 08208 Sabadell, Catalonia, Spain
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Agency for Health Quality and Assessment of Catalonia (AQUAS), 08005 Barcelona, Catalonia, Spain
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Serra Hunter Fellow, Department of Medicine, University of Barcelona, 08036 Barcelona, Catalonia, Spain
*
Authors to whom correspondence should be addressed.
Academic Editor: Shaker A. Mousa
Biomedicines 2021, 9(5), 509; https://doi.org/10.3390/biomedicines9050509
Received: 4 April 2021 / Revised: 25 April 2021 / Accepted: 3 May 2021 / Published: 5 May 2021
(This article belongs to the Section Molecular and Translational Medicine)
Treatment with calcitriol, the hormonal form of vitamin D, has shown beneficial effects in experimental models of acute lung injury. In this study, we aimed to analyze the associations between calcitriol supplementation and the risk of SARS-CoV2 infection or COVID-19 mortality. Individuals ≥18 years old living in Catalonia and supplemented with calcitriol from April 2019 to February 2020 were compared with propensity score matched controls. Outcome variables were SARS-CoV2 infection, severe COVID-19 and COVID-19 mortality. Associations between calcitriol supplementation and outcome variables were analyzed using multivariable Cox proportional regression. A total of 8076 patients were identified as being on calcitriol treatment. Advanced chronic kidney disease and hypoparathyroidism were the most frequent reasons for calcitriol supplementation in our population. Calcitriol use was associated with reduced risk of SARS-CoV2 infection (HR 0.78 [CI 95% 0.64–0.94], p = 0.010), reduced risk of severe COVID-19 and reduced COVID-19 mortality (HR 0.57 (CI 95% 0.41–0.80), p = 0.001) in patients with advanced chronic kidney disease. In addition, an inverse association between mean daily calcitriol dose and COVID-19 severity or mortality was observed in treated patients, independently of renal function. Our findings point out that patients with advanced chronic kidney disease could benefit from calcitriol supplementation during the COVID-19 pandemic. View Full-Text
Keywords: calcitriol; vitamin D; COVID-19; SARS-CoV2 infection; chronic kidney disease calcitriol; vitamin D; COVID-19; SARS-CoV2 infection; chronic kidney disease
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MDPI and ACS Style

Oristrell, J.; Oliva, J.C.; Subirana, I.; Casado, E.; Domínguez, D.; Toloba, A.; Aguilera, P.; Esplugues, J.; Fafián, P.; Grau, M. Association of Calcitriol Supplementation with Reduced COVID-19 Mortality in Patients with Chronic Kidney Disease: A Population-Based Study. Biomedicines 2021, 9, 509. https://doi.org/10.3390/biomedicines9050509

AMA Style

Oristrell J, Oliva JC, Subirana I, Casado E, Domínguez D, Toloba A, Aguilera P, Esplugues J, Fafián P, Grau M. Association of Calcitriol Supplementation with Reduced COVID-19 Mortality in Patients with Chronic Kidney Disease: A Population-Based Study. Biomedicines. 2021; 9(5):509. https://doi.org/10.3390/biomedicines9050509

Chicago/Turabian Style

Oristrell, Joaquim; Oliva, Joan C.; Subirana, Isaac; Casado, Enrique; Domínguez, Didier; Toloba, Andrea; Aguilera, Patricia; Esplugues, Joan; Fafián, Pilar; Grau, Maria. 2021. "Association of Calcitriol Supplementation with Reduced COVID-19 Mortality in Patients with Chronic Kidney Disease: A Population-Based Study" Biomedicines 9, no. 5: 509. https://doi.org/10.3390/biomedicines9050509

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