Emerging Role of C5 Complement Pathway in Peripheral Neuropathies: Current Treatments and Future Perspectives
, Mara Zippoli 1,†, Pasquale Cocchiaro 1, Vanessa Castelli 2, Giustino Varrassi 3, Andrea Aramini 4, Marcello Allegretti 4, Laura Brandolini 4 and Maria Candida Cesta 4,*Round 1
Reviewer 1 Report
Complement-related diseases have been the focus of much attention in recent years, and therapeutic agents for these diseases have attracted much attention. Especially, in peripheral nerve diseases, innovative therapeutic results have been shown. This review summarizes and describes almost all of the current anti-complement C5 molecular target drugs, and will be very useful for researchers in this field.
Author Response
Dear Reviewer, thank you very much for your feedback on our paper, apprecited.
Kind regards
Reviewer 2 Report
In this manuscript, the authors provide an overview of complement pathways and major components associated with dysregulated complement activation in peripheral neuropathy. They also provided a comprehensive review for drugs under development, which are targeting C5 system. C5/C5aR1 axis modulators could represent a new strategy to treat complement-related peripheral neuropathies. Specifically, Giorgio et al describe novel C5aR allosteric modulators, which may potentially become new tools in the therapeutic armory against neuropathic pain.
Author Response
Dear Reviewer 2, thank you for the time spent in revising our manuscript and for the request to slightly review the English language to improve it. We have accepted your suggestions trying to improve the style. The changes made are reported in the attached file.
Author Response File: 
Author Response.docx
