Next Article in Journal
Dulaglutide Alone and in Combination with Empagliflozin Attenuate Inflammatory Pathways and Microbiome Dysbiosis in a Non-Diabetic Mouse Model of NASH
Previous Article in Journal
miR-30b-5p Downregulation as a Predictive Biomarker of Coronary In-Stent Restenosis
Previous Article in Special Issue
The Effect of Small Molecule Pharmacological Agents on the Triterpenoid Saponin Induced Endolysosomal Escape of Saporin and a Saporin-Based Immunotoxin in Target Human Lymphoma Cells
Open AccessArticle

Nectin Cell Adhesion Molecule 4 (NECTIN4) Expression in Cutaneous Squamous Cell Carcinoma: A New Therapeutic Target?

1
Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
2
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
3
Research and Clinical Center for Yusho and Dioxin, Kyushu University Hospital, Fukuoka 812-8582, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Letizia Polito
Biomedicines 2021, 9(4), 355; https://doi.org/10.3390/biomedicines9040355
Received: 8 March 2021 / Revised: 22 March 2021 / Accepted: 26 March 2021 / Published: 30 March 2021
Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer, and its incidence is rising because of the aging population. Nectin cell adhesion molecule 4 (NECTIN4) is involved in the progression of tumors and has attracted interest as a potential therapeutic target. However, little is known about the expression and significance of NECTIN4 in cSCC. The aim of this study was to determine the expression and function of NECTIN4 in cSCC. Immunohistological NECTIN4 expression was investigated in tissues from 34 cSCC patients. Using an A431 human SCC cell line, the role of NECTIN4 in the regulation of cell–cell attachment and migration and proliferation was assessed. NECTIN4 was expressed in most cSCC tissues and on the plasma membrane of A431 cells. Silencing of NECTIN4 prevented cell–cell attachment and induced the expression migration-related molecules, leading to an increase in cell migration. Knockdown of NECTIN4 downregulated extracellular signal-regulated kinase signaling, decreased cyclin D1 expression, and inhibited cell proliferation. These results show that NECTIN4 is expressed in cSCC and functions in the regulation of cell–cell interactions, as well as in the migration and proliferation of SCC cells. NECTIN4-targeted therapy may serve as a novel and promising treatment for cSCC. View Full-Text
Keywords: NECTIN4; cutaneous squamous cell carcinoma; antibody-drug conjugate; targeted therapy NECTIN4; cutaneous squamous cell carcinoma; antibody-drug conjugate; targeted therapy
Show Figures

Figure 1

MDPI and ACS Style

Tanaka, Y.; Murata, M.; Oda, Y.; Furue, M.; Ito, T. Nectin Cell Adhesion Molecule 4 (NECTIN4) Expression in Cutaneous Squamous Cell Carcinoma: A New Therapeutic Target? Biomedicines 2021, 9, 355. https://doi.org/10.3390/biomedicines9040355

AMA Style

Tanaka Y, Murata M, Oda Y, Furue M, Ito T. Nectin Cell Adhesion Molecule 4 (NECTIN4) Expression in Cutaneous Squamous Cell Carcinoma: A New Therapeutic Target? Biomedicines. 2021; 9(4):355. https://doi.org/10.3390/biomedicines9040355

Chicago/Turabian Style

Tanaka, Yuka; Murata, Maho; Oda, Yoshinao; Furue, Masutaka; Ito, Takamichi. 2021. "Nectin Cell Adhesion Molecule 4 (NECTIN4) Expression in Cutaneous Squamous Cell Carcinoma: A New Therapeutic Target?" Biomedicines 9, no. 4: 355. https://doi.org/10.3390/biomedicines9040355

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop