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MiR-7 in Cancer Development

Department of Biology, Division of Molecular Biology, Faculty of Science, University of Zagreb, Horvatovac 102, 10000 Zagreb, Croatia
Division of Molecular Biology, Rudjer Bosković Institute, Bijenička 54, 10000 Zagreb, Croatia
Author to whom correspondence should be addressed.
Academic Editor: Francesca Lovat
Biomedicines 2021, 9(3), 325;
Received: 26 February 2021 / Revised: 20 March 2021 / Accepted: 22 March 2021 / Published: 23 March 2021
(This article belongs to the Special Issue MicroRNA in Solid Tumor and Hematological Diseases)
MicroRNAs (miRNAs) are short non-coding RNA involved in the regulation of specific mRNA translation. They participate in cellular signaling circuits and can act as oncogenes in tumor development, so-called oncomirs, as well as tumor suppressors. miR-7 is an ancient miRNA involved in the fine-tuning of several signaling pathways, acting mainly as tumor suppressor. Through downregulation of PI3K and MAPK pathways, its dominant role is the suppression of proliferation and survival, stimulation of apoptosis and inhibition of migration. Besides these functions, it has numerous additional roles in the differentiation process of different cell types, protection from stress and chromatin remodulation. One of the most investigated tissues is the brain, where its downregulation is linked with glioblastoma cell proliferation. Its deregulation is found also in other tumor types, such as in liver, lung and pancreas. In some types of lung and oral carcinoma, it can act as oncomir. miR-7 roles in cell fate determination and maintenance of cell homeostasis are still to be discovered, as well as the possibilities of its use as a specific biotherapeutic. View Full-Text
Keywords: microRNAs; miR-7; gene expression; tumor suppressor; cancer cell microRNAs; miR-7; gene expression; tumor suppressor; cancer cell
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MDPI and ACS Style

Korać, P.; Antica, M.; Matulić, M. MiR-7 in Cancer Development. Biomedicines 2021, 9, 325.

AMA Style

Korać P, Antica M, Matulić M. MiR-7 in Cancer Development. Biomedicines. 2021; 9(3):325.

Chicago/Turabian Style

Korać, Petra, Mariastefania Antica, and Maja Matulić. 2021. "MiR-7 in Cancer Development" Biomedicines 9, no. 3: 325.

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