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Review

A New Rise of Non-Human Primate Models of Synucleinopathies

Université de Bordeaux, CNRS, IMN, UMR 5293, F-33000 Bordeaux, France
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Author to whom correspondence should be addressed.
Academic Editor: Marc Ekker
Biomedicines 2021, 9(3), 272; https://doi.org/10.3390/biomedicines9030272
Received: 20 January 2021 / Revised: 27 February 2021 / Accepted: 4 March 2021 / Published: 9 March 2021
(This article belongs to the Special Issue Animal Models of Parkinson's Disease)
Synucleinopathies are neurodegenerative diseases characterized by the presence of α-synuclein-positive intracytoplasmic inclusions in the central nervous system. Multiple experimental models have been extensively used to understand better the mechanisms involved in the pathogenesis of synucleinopathy. Non-human primate (NHP) models are of interest in neurodegenerative diseases as they constitute the highest relevant preclinical model in translational research. They also contribute to bringing new insights into synucleinopathy’s pathogenicity and help in the quest and validation of therapeutical strategies. Here, we reviewed the different NHP models that have recapitulated key characteristics of synucleinopathy, and we aimed to highlight the contribution of NHP in mechanistic and translational approaches for synucleinopathies. View Full-Text
Keywords: non-human primates; synucleinopathy; neurodegeneration; α-synuclein; animal model non-human primates; synucleinopathy; neurodegeneration; α-synuclein; animal model
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MDPI and ACS Style

Teil, M.; Arotcarena, M.-L.; Dehay, B. A New Rise of Non-Human Primate Models of Synucleinopathies. Biomedicines 2021, 9, 272. https://doi.org/10.3390/biomedicines9030272

AMA Style

Teil M, Arotcarena M-L, Dehay B. A New Rise of Non-Human Primate Models of Synucleinopathies. Biomedicines. 2021; 9(3):272. https://doi.org/10.3390/biomedicines9030272

Chicago/Turabian Style

Teil, Margaux, Marie-Laure Arotcarena, and Benjamin Dehay. 2021. "A New Rise of Non-Human Primate Models of Synucleinopathies" Biomedicines 9, no. 3: 272. https://doi.org/10.3390/biomedicines9030272

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