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Insights into the Roles of the Sideroflexins/SLC56 Family in Iron Homeostasis and Iron-Sulfur Biogenesis

1
LGBC, UVSQ, Université Paris-Saclay, 78000 Versailles, France
2
École Pratique des Hautes Études, PSL University, 75014 Paris, France
3
GCGP Department, IUT de Vélizy/Rambouillet, UVSQ, Université Paris-Saclay, 78120 Rambouillet, France
*
Author to whom correspondence should be addressed.
These authors equally contributed to this work.
Academic Editor: Marie-Pierre Golinelli-Cohen
Biomedicines 2021, 9(2), 103; https://doi.org/10.3390/biomedicines9020103
Received: 21 December 2020 / Revised: 18 January 2021 / Accepted: 19 January 2021 / Published: 21 January 2021
(This article belongs to the Special Issue Fe-S Proteins in Health and Disease)
Sideroflexins (SLC56 family) are highly conserved multi-spanning transmembrane proteins inserted in the inner mitochondrial membrane in eukaryotes. Few data are available on their molecular function, but since their first description, they were thought to be metabolite transporters probably required for iron utilization inside the mitochondrion. Such as numerous mitochondrial transporters, sideroflexins remain poorly characterized. The prototypic member SFXN1 has been recently identified as the previously unknown mitochondrial transporter of serine. Nevertheless, pending questions on the molecular function of sideroflexins remain unsolved, especially their link with iron metabolism. Here, we review the current knowledge on sideroflexins, their presumed mitochondrial functions and the sparse—but growing—evidence linking sideroflexins to iron homeostasis and iron-sulfur cluster biogenesis. Since an imbalance in iron homeostasis can be detrimental at the cellular and organismal levels, we also investigate the relationship between sideroflexins, iron and physiological disorders. Investigating Sideroflexins’ functions constitutes an emerging research field of great interest and will certainly lead to the main discoveries of mitochondrial physio-pathology. View Full-Text
Keywords: sideroflexin; mitochondria; mitochondrial transporters; iron homeostasis; iron-sulfur cluster; heme biosynthesis; one-carbon metabolism; ferroptosis; ferritinophagy sideroflexin; mitochondria; mitochondrial transporters; iron homeostasis; iron-sulfur cluster; heme biosynthesis; one-carbon metabolism; ferroptosis; ferritinophagy
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MDPI and ACS Style

Tifoun, N.; De las Heras, J.M.; Guillaume, A.; Bouleau, S.; Mignotte, B.; Le Floch, N. Insights into the Roles of the Sideroflexins/SLC56 Family in Iron Homeostasis and Iron-Sulfur Biogenesis. Biomedicines 2021, 9, 103. https://doi.org/10.3390/biomedicines9020103

AMA Style

Tifoun N, De las Heras JM, Guillaume A, Bouleau S, Mignotte B, Le Floch N. Insights into the Roles of the Sideroflexins/SLC56 Family in Iron Homeostasis and Iron-Sulfur Biogenesis. Biomedicines. 2021; 9(2):103. https://doi.org/10.3390/biomedicines9020103

Chicago/Turabian Style

Tifoun, Nesrine; De las Heras, José M.; Guillaume, Arnaud; Bouleau, Sylvina; Mignotte, Bernard; Le Floch, Nathalie. 2021. "Insights into the Roles of the Sideroflexins/SLC56 Family in Iron Homeostasis and Iron-Sulfur Biogenesis" Biomedicines 9, no. 2: 103. https://doi.org/10.3390/biomedicines9020103

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