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Article

The Effectiveness of Compartmentalized Bone Graft Sponges Made Using Complementary Bone Graft Materials and Succinylated Chitosan Hydrogels

1
Department of Dentistry, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea
2
Department of Clinical Pathology, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea
3
Department of Dental Materials, School of Dentistry, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea
4
Department of Dental Education, School of Dentistry, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemum-gu, Seoul 02447, Korea
5
Department of Biological Science, Sookmyung Women’s University, Cheongpa-ro 47-gil 100 (Cheongpa-dong 2(i)-ga), Yongsan-gu, Seoul 04310, Korea
*
Authors to whom correspondence should be addressed.
These authors equally contributed to this work.
These corresponding authors have made equal contributions to this work.
Academic Editor: Mike Barbeck
Biomedicines 2021, 9(12), 1765; https://doi.org/10.3390/biomedicines9121765 (registering DOI)
Received: 14 October 2021 / Revised: 16 November 2021 / Accepted: 22 November 2021 / Published: 25 November 2021
(This article belongs to the Section Biomedical Materials)
Bone defects can occur from many causes, including disease or trauma. Bone graft materials (BGMs) have been used to fill damaged areas for the reconstruction of diseased bone tissues since they are cost effective and readily available. However, BGMs quickly disperse around the tissue area, which ultimately leads to it migrating away from the defect after transplantation. We tested chitosan hydrogels as a useful carrier to hold BGMs in the transplantation area. In this study, we synthesized succinylated chitosan (SCS)-based hydrogels with a high decomposition rate and excellent biocompatibility. We confirmed that BGMs were well distributed inside the SCS hydrogel. The SCS-B hydrogel showed a decrease in mechanical properties, such as compressive strength and Young’s modulus, as the succinylation rate increased. SCS-B hydrogels also exhibited a high cell growth rate and bone differentiation rate. Moreover, the in vivo results showed that the SCS hydrogel resorbed into the surrounding tissues while maintaining the BGMs in the transplantation area for up to 6 weeks. These data support the idea that SCS hydrogel can be useful as a bioactive drug carrier for a broad range of biomedical applications. View Full-Text
Keywords: natural polymer-based hydrogel; chitosan; bone graft; succinylation; bone tissue engineering natural polymer-based hydrogel; chitosan; bone graft; succinylation; bone tissue engineering
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MDPI and ACS Style

Lee, J.S.; Kim, H.-S.; Nah, H.; Lee, S.J.; Moon, H.-J.; Bang, J.B.; Lee, J.B.; Do, S.H.; Kwon, I.K.; Heo, D.N. The Effectiveness of Compartmentalized Bone Graft Sponges Made Using Complementary Bone Graft Materials and Succinylated Chitosan Hydrogels. Biomedicines 2021, 9, 1765. https://doi.org/10.3390/biomedicines9121765

AMA Style

Lee JS, Kim H-S, Nah H, Lee SJ, Moon H-J, Bang JB, Lee JB, Do SH, Kwon IK, Heo DN. The Effectiveness of Compartmentalized Bone Graft Sponges Made Using Complementary Bone Graft Materials and Succinylated Chitosan Hydrogels. Biomedicines. 2021; 9(12):1765. https://doi.org/10.3390/biomedicines9121765

Chicago/Turabian Style

Lee, Jae S., Hyo-Sung Kim, Haram Nah, Sang J. Lee, Ho-Jin Moon, Jae B. Bang, Jung B. Lee, Sun H. Do, Il K. Kwon, and Dong N. Heo 2021. "The Effectiveness of Compartmentalized Bone Graft Sponges Made Using Complementary Bone Graft Materials and Succinylated Chitosan Hydrogels" Biomedicines 9, no. 12: 1765. https://doi.org/10.3390/biomedicines9121765

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