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Article

Serum-Derived Neuronal Exosomal microRNAs as Stress-Related Biomarkers in an Atopic Dermatitis Model

1
Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu 41061, Korea
2
Department of Psychiatry, School of Medicine, Kyungpook National University, Daegu 41944, Korea
3
College of Veterinary Medicine, Kyungpook National University, 80 Daehakro, Buk-gu, Daegu 41566, Korea
4
New Drug Development Center, Osong Medical Innovation Foundation, Cheongju 28160, Korea
5
Department of Orthopedic Surgery, Yeungnam University Medical Center, Yeungnam University College of Medicine, 170 Hyonchung-ro, Namgu, Daegu 42415, Korea
6
Department of Medical Statistics, School of Medicine, Catholic University of Daegu, Daegu 42472, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Santosh Aryal
Biomedicines 2021, 9(12), 1764; https://doi.org/10.3390/biomedicines9121764
Received: 2 November 2021 / Revised: 13 November 2021 / Accepted: 23 November 2021 / Published: 25 November 2021
Chronic allergic inflammatory skin disease—atopic dermatitis (AD)—is characterized by eczema, pruritus, xeroderma, and lichenification. Psychological stress is one cause of this disease; however, psychological stress will also result from the presence of AD symptoms. Previous studies have shown that psychological stress triggers neuroinflammation in the brain, where microRNAs (miRNAs) in the neuronal exosomes (nEVs) were analyzed to identify the composition of the miRNAs in the nEVs and how they were altered by AD. In this study, the AD model was induced by treatment with 2,4-dinitrochlorobenzene (DNCB). The expression patterns of neuroinflammation markers, such as brain-derived neurotrophic factor, cyclooxygenase-2, and glial fibrillary acidic protein, were subsequently evaluated over time. Among these groups, there was a significant difference in DNCB 14 days expression compared with the control; therefore, nEVs were isolated from serum and next-generation sequencing was performed. The results demonstrate that 9 miRNAs were upregulated and 16 were downregulated in the DNCB 14 days compared with the control. Previous studies have shown that some of these miRNAs are associated with stress and stress-induced depression, which suggests that the miRNAs in nEVs may also be stress-related biomarkers. View Full-Text
Keywords: atopic dermatitis; stress; exosomes; miRNA; biomarkers atopic dermatitis; stress; exosomes; miRNA; biomarkers
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MDPI and ACS Style

Sung, M.; Sung, S.-E.; Kang, K.-K.; Choi, J.-H.; Lee, S.; Kim, K.; Lim, J.-H.; Lee, G.W.; Rim, H.-D.; Won, S.; Kim, B.-S.; Kim, K.; Jang, S.; Kwak, S.G.; Woo, J.; Seo, M.-S. Serum-Derived Neuronal Exosomal microRNAs as Stress-Related Biomarkers in an Atopic Dermatitis Model. Biomedicines 2021, 9, 1764. https://doi.org/10.3390/biomedicines9121764

AMA Style

Sung M, Sung S-E, Kang K-K, Choi J-H, Lee S, Kim K, Lim J-H, Lee GW, Rim H-D, Won S, Kim B-S, Kim K, Jang S, Kwak SG, Woo J, Seo M-S. Serum-Derived Neuronal Exosomal microRNAs as Stress-Related Biomarkers in an Atopic Dermatitis Model. Biomedicines. 2021; 9(12):1764. https://doi.org/10.3390/biomedicines9121764

Chicago/Turabian Style

Sung, Minkyoung, Soo-Eun Sung, Kyung-Ku Kang, Joo-Hee Choi, Sijoon Lee, KilSoo Kim, Ju-Hyeon Lim, Gun W. Lee, Hyo-Deog Rim, Seunghee Won, Byung-Soo Kim, Kyungmin Kim, Seoyoung Jang, Sang G. Kwak, Jungmin Woo, and Min-Soo Seo. 2021. "Serum-Derived Neuronal Exosomal microRNAs as Stress-Related Biomarkers in an Atopic Dermatitis Model" Biomedicines 9, no. 12: 1764. https://doi.org/10.3390/biomedicines9121764

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