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The Pharmacological Effects and Pharmacokinetics of Active Compounds of Artemisia capillaris

by 1,2,3, 4,5, 6,7 and 1,6,8,*
1
Institute of Traditional Medicine, School of Medicine, National Yang-Ming Chiao-Tung University, Taipei 112, Taiwan
2
School of Traditional Chinese Medicine, Chang Gung University, Taoyuan 333, Taiwan
3
Department of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan
4
Department of Traditional Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan
5
Institute of Education, National Sun Yat-sen University, Kaohsiung 804, Taiwan
6
Department of Psychology, University of Cambridge, Cambridge CB2 3EB, UK
7
Department of Psychiatry, University of Cambridge, Cambridge CB2 0SZ, UK
8
Department of Education and Research, Taipei City Hospital, Taipei 103, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editors: Hye Hyun Yoo and Giuliana Cangemi
Biomedicines 2021, 9(10), 1412; https://doi.org/10.3390/biomedicines9101412
Received: 1 September 2021 / Revised: 22 September 2021 / Accepted: 28 September 2021 / Published: 8 October 2021
(This article belongs to the Special Issue Pharmacokinetics and Therapeutic Drug Monitoring)
Artemisia capillaris Thunb. (A.capillaris, Yin-Chen in Chinese) is a traditional medicinal herb with a wide spectrum of pharmacological properties ranging from effects against liver dysfunction to treatments of severe cirrhosis and cancer. We used relevant keywords to search electronic databases, including PubMed, Medline, and Google Scholar, for scientific contributions related to this medicinal herb and the pharmacokinetics of its components. The pharmaceutical effects of A.capillaris contribute to the treatment not only of viral hepatitis, cirrhosis, and hepatocellular hepatoma, but also metabolic syndrome, psoriasis, and enterovirus in the clinic. The bioactive compounds, including scoparone, capillarisin, scopoletin, and chlorogenic acid, exhibit antioxidant, anti-inflammatory, antisteatotic, antiviral, and antitumor properties, reflecting the pharmacological effects of A.capillaris. The pharmacokinetics of the main bioactive compounds in A. capillaris can achieve a maximum concentration within 1 hour, but only chlorogenic acid has a relatively long half-life. Regarding the use of the A. capillaris herb by health professionals to treat various diseases, the dosing schedule of this herb should be carefully considered to maximize therapeutic outcomes while lessening possible side effects. View Full-Text
Keywords: Artemisia; pharmacokinetics; pharmacology; herbal medicine; Yin-Chen; scoparone Artemisia; pharmacokinetics; pharmacology; herbal medicine; Yin-Chen; scoparone
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MDPI and ACS Style

Hsueh, T.-P.; Lin, W.-L.; Dalley, J.W.; Tsai, T.-H. The Pharmacological Effects and Pharmacokinetics of Active Compounds of Artemisia capillaris. Biomedicines 2021, 9, 1412. https://doi.org/10.3390/biomedicines9101412

AMA Style

Hsueh T-P, Lin W-L, Dalley JW, Tsai T-H. The Pharmacological Effects and Pharmacokinetics of Active Compounds of Artemisia capillaris. Biomedicines. 2021; 9(10):1412. https://doi.org/10.3390/biomedicines9101412

Chicago/Turabian Style

Hsueh, Tun-Pin, Wan-Ling Lin, Jeffrey W. Dalley, and Tung-Hu Tsai. 2021. "The Pharmacological Effects and Pharmacokinetics of Active Compounds of Artemisia capillaris" Biomedicines 9, no. 10: 1412. https://doi.org/10.3390/biomedicines9101412

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