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Open AccessArticle

Rational Design of Albumin Theranostic Conjugates for Gold Nanoparticles Anticancer Drugs: Where the Seed Meets the Soil?

1
Institute of Chemical Biology and Fundamental Medicine, The Siberian Branch of the Russian Academy of Sciences, Lavrentiev ave. 8, 630090 Novosibirsk, Russia
2
Institute of Cytology and Genetics, SB RAS, Lavrentiev ave. 10, 630090 Novosibirsk, Russia
*
Author to whom correspondence should be addressed.
Biomedicines 2021, 9(1), 74; https://doi.org/10.3390/biomedicines9010074
Received: 29 November 2020 / Revised: 31 December 2020 / Accepted: 10 January 2021 / Published: 13 January 2021
(This article belongs to the Special Issue Theranostic Drug Delivery: Prospects and Problems)
Multifunctional gold nanoparticles (AuNPs) may serve as a scaffold to integrate diagnostic and therapeutic functions into one theranostic system, thereby simultaneously facilitating diagnosis and therapy and monitoring therapeutic responses. Herein, albumin-AuNP theranostic agents have been obtained by conjugation of an anticancer nucleotide trifluorothymidine (TFT) or a boron-neutron capture therapy drug undecahydro-closo-dodecaborate (B12H12) to bimodal human serum albumin (HSA) followed by reacting of the albumin conjugates with AuNPs. In vitro studies have revealed a stronger cytotoxicity by the AuNPs decorated with the TFT-tagged bimodal HSA than by the boronated albumin conjugates. Despite long circulation time, lack of the significant accumulation in the tumor was observed for the AuNP theranostic conjugates. Our unique labelling strategy allows for monitoring of spatial distribution of the AuNPs theranostic in vivo in real time with high sensitivity, thus reducing the number of animals required for testing and optimizing new nanosystems as chemotherapeutic agents and boron-neutron capture therapy drug candidates. View Full-Text
Keywords: gold nanoparticles; albumin theranostic conjugates; boronated albumin conjugate; trifluorothymidine-albumin conjugate; fluorescence-based molecular imaging gold nanoparticles; albumin theranostic conjugates; boronated albumin conjugate; trifluorothymidine-albumin conjugate; fluorescence-based molecular imaging
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MDPI and ACS Style

Popova, T.V.; Pyshnaya, I.A.; Zakharova, O.D.; Akulov, A.E.; Shevelev, O.B.; Poletaeva, J.; Zavjalov, E.L.; Silnikov, V.N.; Ryabchikova, E.I.; Godovikova, T.S. Rational Design of Albumin Theranostic Conjugates for Gold Nanoparticles Anticancer Drugs: Where the Seed Meets the Soil? Biomedicines 2021, 9, 74. https://doi.org/10.3390/biomedicines9010074

AMA Style

Popova TV, Pyshnaya IA, Zakharova OD, Akulov AE, Shevelev OB, Poletaeva J, Zavjalov EL, Silnikov VN, Ryabchikova EI, Godovikova TS. Rational Design of Albumin Theranostic Conjugates for Gold Nanoparticles Anticancer Drugs: Where the Seed Meets the Soil? Biomedicines. 2021; 9(1):74. https://doi.org/10.3390/biomedicines9010074

Chicago/Turabian Style

Popova, Tatyana V.; Pyshnaya, Inna A.; Zakharova, Olga D.; Akulov, Andrey E.; Shevelev, Oleg B.; Poletaeva, Julia; Zavjalov, Evgenii L.; Silnikov, Vladimir N.; Ryabchikova, Elena I.; Godovikova, Tatyana S. 2021. "Rational Design of Albumin Theranostic Conjugates for Gold Nanoparticles Anticancer Drugs: Where the Seed Meets the Soil?" Biomedicines 9, no. 1: 74. https://doi.org/10.3390/biomedicines9010074

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