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Open AccessArticle

Shared Blood Transcriptomic Signatures between Alzheimer’s Disease and Diabetes Mellitus

by 1 and 1,2,3,*
1
Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Korea
2
Artificial Intelligence Graduate School, Gwangju Institute of Science and Technology, Gwangju 61005, Korea
3
School of Electrical Engineering and Computer Science, Gwangju Institute of Science and Technology, Gwangju 61005, Korea
*
Author to whom correspondence should be addressed.
Data used in preparation of this article were obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database. As such, the investigators within the ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in analysis or writing of this report.
Biomedicines 2021, 9(1), 34; https://doi.org/10.3390/biomedicines9010034
Received: 2 December 2020 / Revised: 29 December 2020 / Accepted: 30 December 2020 / Published: 4 January 2021
(This article belongs to the Section Neurobiology and Neurologic Disease)
Alzheimer’s disease (AD) and diabetes mellitus (DM) are known to have a shared molecular mechanism. We aimed to identify shared blood transcriptomic signatures between AD and DM. Blood expression datasets for each disease were combined and a co-expression network was used to construct modules consisting of genes with similar expression patterns. For each module, a gene regulatory network based on gene expression and protein-protein interactions was established to identify hub genes. We selected one module, where COPS4, PSMA6, GTF2B, GTF2F2, and SSB were identified as dysregulated transcription factors that were common between AD and DM. These five genes were also differentially co-expressed in disease-related tissues, such as the brain in AD and the pancreas in DM. Our study identified gene modules that were dysregulated in both AD and DM blood samples, which may contribute to reveal common pathophysiology between two diseases. View Full-Text
Keywords: Alzheimer’s disease; diabetes mellitus; blood gene expression Alzheimer’s disease; diabetes mellitus; blood gene expression
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MDPI and ACS Style

Lee, T.; Lee, H. Shared Blood Transcriptomic Signatures between Alzheimer’s Disease and Diabetes Mellitus. Biomedicines 2021, 9, 34. https://doi.org/10.3390/biomedicines9010034

AMA Style

Lee T, Lee H. Shared Blood Transcriptomic Signatures between Alzheimer’s Disease and Diabetes Mellitus. Biomedicines. 2021; 9(1):34. https://doi.org/10.3390/biomedicines9010034

Chicago/Turabian Style

Lee, Taesic; Lee, Hyunju. 2021. "Shared Blood Transcriptomic Signatures between Alzheimer’s Disease and Diabetes Mellitus" Biomedicines 9, no. 1: 34. https://doi.org/10.3390/biomedicines9010034

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