Next Article in Journal
Impact of Subclinical Congestion on Outcome of Patients Undergoing Mitral Valve Surgery
Previous Article in Journal
COL2A1 Is a Novel Biomarker of Melanoma Tumor Repopulating Cells
Previous Article in Special Issue
Highlighting Human Enzymes Active in Different Metabolic Pathways and Diseases: The Case Study of EC 1.2.3.1 and EC 2.3.1.9
Review

Protein Dynamics in F-like Bacterial Conjugation

1
Department of Chemistry and the Centre for Research on Biomolecular Interactions, York University, Toronto, ON M3J 1P3, Canada
2
Department of Chemistry, York University, Toronto, ON M3J 1P3, Canada
*
Author to whom correspondence should be addressed.
Biomedicines 2020, 8(9), 362; https://doi.org/10.3390/biomedicines8090362
Received: 28 August 2020 / Revised: 15 September 2020 / Accepted: 17 September 2020 / Published: 19 September 2020
(This article belongs to the Special Issue Protein Structure, Function and Dynamics in Diseases and Therapeutics)
Efficient in silico development of novel antibiotics requires high-resolution, dynamic models of drug targets. As conjugation is considered the prominent contributor to the spread of antibiotic resistance genes, targeted drug design to disrupt vital components of conjugative systems has been proposed to lessen the proliferation of bacterial antibiotic resistance. Advancements in structural imaging techniques of large macromolecular complexes has accelerated the discovery of novel protein-protein interactions in bacterial type IV secretion systems (T4SS). The known structural information regarding the F-like T4SS components and complexes has been summarized in the following review, revealing a complex network of protein-protein interactions involving domains with varying degrees of disorder. Structural predictions were performed to provide insight on the dynamicity of proteins within the F plasmid conjugative system that lack structural information. View Full-Text
Keywords: bacterial conjugation; type IV secretion system (T4SS); F plasmid; pilus protein structure; protein dynamics; protein-protein interactions; targeted drug design bacterial conjugation; type IV secretion system (T4SS); F plasmid; pilus protein structure; protein dynamics; protein-protein interactions; targeted drug design
Show Figures

Figure 1

MDPI and ACS Style

Bragagnolo, N.; Rodriguez, C.; Samari-Kermani, N.; Fours, A.; Korouzhdehi, M.; Lysenko, R.; Audette, G.F. Protein Dynamics in F-like Bacterial Conjugation. Biomedicines 2020, 8, 362. https://doi.org/10.3390/biomedicines8090362

AMA Style

Bragagnolo N, Rodriguez C, Samari-Kermani N, Fours A, Korouzhdehi M, Lysenko R, Audette GF. Protein Dynamics in F-like Bacterial Conjugation. Biomedicines. 2020; 8(9):362. https://doi.org/10.3390/biomedicines8090362

Chicago/Turabian Style

Bragagnolo, Nicholas, Christina Rodriguez, Naveed Samari-Kermani, Alice Fours, Mahboubeh Korouzhdehi, Rachel Lysenko, and Gerald F. Audette 2020. "Protein Dynamics in F-like Bacterial Conjugation" Biomedicines 8, no. 9: 362. https://doi.org/10.3390/biomedicines8090362

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop