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Biomedicines
Volume 8
Issue 9
10.3390/biomedicines8090343
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Article

Type 1 Diabetes Induces Hearing Loss: Functional and Histological Findings in An Akita Mouse Model

by
Yun Yeong Lee
1,
Yeon Ju Kim
1,
Eun Sol Gil
1,2,
Hantai Kim
1,
Jeong Hun Jang
1 and
Yun-Hoon Choung
1,2,*
1
Department of Otolaryngology, Ajou University School of Medicine, Suwon 16499, Korea
2
Department of Biomedical Science, Ajou University Graduate School of Medicine, Suwon 16499, Korea
*
Author to whom correspondence should be addressed.
Biomedicines 2020, 8(9), 343; https://doi.org/10.3390/biomedicines8090343
Submission received: 13 August 2020 / Revised: 9 September 2020 / Accepted: 9 September 2020 / Published: 11 September 2020
(This article belongs to the Section Molecular and Translational Medicine)
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Abstract

The relationship between type 1 diabetes and hearing loss is not well known, although based on many pathological studies, type 2 diabetes induced hearing loss is associated with microcirculation problems in the inner ear. The purpose of this study was to investigate the correlation between type 1 diabetes and hearing loss through hearing function and immunohistochemical analyses using type 1 diabetic Akita or wild-type (WT) mice. The Akita mice had a significant increase in hearing thresholds, blood glucose, and insulin tolerance compared to WT mice. Histological analysis showed that the loss of cells and damage to mitochondria in the spiral ganglion neurons of Akita mice were significantly increased compared to WT. Also, the stria vascularis showed decreased thickness, loss of intermediate cells, and disturbance in blood capillary shape in the Akita mice. Moreover, a reduction in type I, II, and IV fibrocytes and Na+/K+-ATPase α1 expression in spiral ligament was also observed. Cleaved caspase-3 expression was highly expressed in spiral ganglion neurons. In conclusion, hearing loss in type 1 diabetes is caused not only by ion imbalance and blood flow disorders of cochlear endolymph, but through the degenerative nervous system via apoptosis-mediated cell death.
Keywords: hearing loss; diabetes; Akita; Na+/K+-ATPase; apoptosis hearing loss; diabetes; Akita; Na+/K+-ATPase; apoptosis

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MDPI and ACS Style

Lee, Y.Y.; Kim, Y.J.; Gil, E.S.; Kim, H.; Jang, J.H.; Choung, Y.-H. Type 1 Diabetes Induces Hearing Loss: Functional and Histological Findings in An Akita Mouse Model. Biomedicines 2020, 8, 343. https://doi.org/10.3390/biomedicines8090343

AMA Style

Lee YY, Kim YJ, Gil ES, Kim H, Jang JH, Choung Y-H. Type 1 Diabetes Induces Hearing Loss: Functional and Histological Findings in An Akita Mouse Model. Biomedicines. 2020; 8(9):343. https://doi.org/10.3390/biomedicines8090343

Chicago/Turabian Style

Lee, Yun Yeong, Yeon Ju Kim, Eun Sol Gil, Hantai Kim, Jeong Hun Jang, and Yun-Hoon Choung. 2020. "Type 1 Diabetes Induces Hearing Loss: Functional and Histological Findings in An Akita Mouse Model" Biomedicines 8, no. 9: 343. https://doi.org/10.3390/biomedicines8090343

APA Style

Lee, Y. Y., Kim, Y. J., Gil, E. S., Kim, H., Jang, J. H., & Choung, Y.-H. (2020). Type 1 Diabetes Induces Hearing Loss: Functional and Histological Findings in An Akita Mouse Model. Biomedicines, 8(9), 343. https://doi.org/10.3390/biomedicines8090343

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