The Anti-Inflammatory and Antioxidant Properties of n-3 PUFAs: Their Role in Cardiovascular Protection
Abstract
:1. Introduction
2. Antioxidant and Antinflammatory Properties of n-3 PUFAs
2.1. Mitochondrial Oxidative Stress and n-3 PUFAs
2.2. Nitric Oxide, Endothelial Dysfunction and n-3 PUFAs
2.3. Cell Membranes and Anti-Inflammatory Effects of n-3 PUFAs
2.4. N-3 PUFA-Derived Mediators
3. Vaso-Protective Activities of n-3 PUFAs
3.1. N-3 PUFAs and Atherosclerosis
3.2. The Effect of n-3 PUFAs in Platelet Function
3.3. N-3 PUFAs Index and Coronary Artery Disease (CAD)
4. The Cardio-Protective Response of n-3 PUFAs Supplementation
4.1. The Effects of n-3 PUFAs in Myocardial Ischemia and Reperfusion
4.2. The Potential for n-3 PUFAs Supplementation in Heart Failure
5. Adverse Effects of PUFAs in Cardiovascular Risk Factors
6. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Oppedisano, F.; Macrì, R.; Gliozzi, M.; Musolino, V.; Carresi, C.; Maiuolo, J.; Bosco, F.; Nucera, S.; Caterina Zito, M.; Guarnieri, L.; et al. The Anti-Inflammatory and Antioxidant Properties of n-3 PUFAs: Their Role in Cardiovascular Protection. Biomedicines 2020, 8, 306. https://doi.org/10.3390/biomedicines8090306
Oppedisano F, Macrì R, Gliozzi M, Musolino V, Carresi C, Maiuolo J, Bosco F, Nucera S, Caterina Zito M, Guarnieri L, et al. The Anti-Inflammatory and Antioxidant Properties of n-3 PUFAs: Their Role in Cardiovascular Protection. Biomedicines. 2020; 8(9):306. https://doi.org/10.3390/biomedicines8090306
Chicago/Turabian StyleOppedisano, Francesca, Roberta Macrì, Micaela Gliozzi, Vincenzo Musolino, Cristina Carresi, Jessica Maiuolo, Francesca Bosco, Saverio Nucera, Maria Caterina Zito, Lorenza Guarnieri, and et al. 2020. "The Anti-Inflammatory and Antioxidant Properties of n-3 PUFAs: Their Role in Cardiovascular Protection" Biomedicines 8, no. 9: 306. https://doi.org/10.3390/biomedicines8090306