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Non-Invasive Delivery of Therapeutics into the Brain: The Potential of Aptamers for Targeted Delivery

1
School of Medicine, Deakin University, 3216 Geelong, Victoria, Australia
2
Centre for Molecular and Medical Research, Deakin University, 3216 Geelong, Victoria, Australia
*
Author to whom correspondence should be addressed.
Biomedicines 2020, 8(5), 120; https://doi.org/10.3390/biomedicines8050120
Received: 29 April 2020 / Revised: 11 May 2020 / Accepted: 12 May 2020 / Published: 14 May 2020
(This article belongs to the Special Issue Engineering Aptamers for Biomedical Applications II)
The blood-brain barrier (BBB) is a highly specialised network of blood vessels that effectively separates the brain environment from the circulatory system. While there are benefits, in terms of keeping pathogens from entering the brain, the BBB also complicates treatments of brain pathologies by preventing efficient delivery of macromolecular drugs to diseased brain tissue. Although current non-invasive strategies of therapeutics delivery into the brain, such as focused ultrasound and nanoparticle-mediated delivery have shown various levels of successes, they still come with risks and limitations. This review discusses the current approaches of therapeutic delivery into the brain, with a specific focus on non-invasive methods. It also discusses the potential for aptamers as alternative delivery systems and several reported aptamers with promising preliminary results. View Full-Text
Keywords: antibody; aptamer; blood-brain barrier; brain pathology; drug delivery; non-invasive; SELEX antibody; aptamer; blood-brain barrier; brain pathology; drug delivery; non-invasive; SELEX
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Bukari, B.; Samarasinghe, R.M.; Noibanchong, J.; Shigdar, S.L. Non-Invasive Delivery of Therapeutics into the Brain: The Potential of Aptamers for Targeted Delivery. Biomedicines 2020, 8, 120.

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