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Open AccessArticle

UVA Photoprotective Activity of Brown Macroalgae Sargassum cristafolium

1
Bioscience and Biotechnology Research Centre, Department of Biology, Faculty of Mathematics and Natural Sciences, University of Mataram, Mataram 83115, Indonesia
2
Department of Pharmacy, Medical Faculty, University of Mataram, Mataram 83115, Indonesia
3
Pharmaceutical Institute, University of Tuebingen, 72074 Tuebingen, Germany
4
Research Unit for Natural Product (BPTBA), Indonesian Institute of Sciences (LIPI), Wonosari 55861, Indonesia
5
Department of Cellular and Integrative Physiology, Fukushima Medical University, Fukushima 960-1247, Japan
*
Author to whom correspondence should be addressed.
Biomedicines 2019, 7(4), 77; https://doi.org/10.3390/biomedicines7040077
Received: 23 August 2019 / Revised: 15 September 2019 / Accepted: 25 September 2019 / Published: 27 September 2019
(This article belongs to the Section Natural Compounds in Biomedicine)
Sunscreens today contain several synthetic UV (Ultraviolet) filter molecules to protect the skin epidermis from UV radiation damage. However, these molecules may create several negative effects on human skin. Due to this condition, there is an increase in the development of natural products to replace uses of these synthetic chemicals. Brown macroalgae Sargassum has been recently studied for its photoprotective activities. The purpose of this study is to investigate photoprotective activity of one of most abundant Sargassum species in Lombok coast; Sargassum cristaefolium. Spectrophotometry analysis with UV-VIS revealed the UV spectra absorbing capability of Sargassum cristaefolium (SC) in the UVA spectrum range (314–400 nm). Furthermore, spectrometry analyses with LC-MS revealed the existence of UV absorbing compound MAA-palythene. In correlation, SC ethanol extracts also demonstrate that it could protect DNA from UVA irradiation as analyzed in vitro in HeLa cell model. The effects of SC on UVA exposed-dorsal mice skin have also shown interesting results, as mice pretreated with SC before UVA exposure showed protective activity on the epidermal integrity similar as positive control. Whereas, UV exposed mice without SC or commercial products resulted in increased epidermal thickness, which is the common parameter of skin photoaging. In addition, pretreated mice with SC also show protective effects in the formation of collagen connective tissues. Overall, current results show promising photoprotective activity of SC against UV radiation. More advanced investigations of SC as a potential photoprotective agent would be reasonable for development of macroalgae-based natural skin protection products. View Full-Text
Keywords: macroalgae; seaweed; sunscreen; photoprotective; ultraviolet macroalgae; seaweed; sunscreen; photoprotective; ultraviolet
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MDPI and ACS Style

Prasedya, E.S.; Syafitri, S.M.; Geraldine, B.A.F.D.; Hamdin, C.D.; Frediansyah, A.; Miyake, M.; Kobayashi, D.; Hazama, A.; Sunarpi, H. UVA Photoprotective Activity of Brown Macroalgae Sargassum cristafolium. Biomedicines 2019, 7, 77.

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