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Notch and Wnt Dysregulation and Its Relevance for Breast Cancer and Tumor Initiation

1
Department of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden
2
Merck KGaA, Biopharma, Global R&D, Translational Innovation Platform Oncology, Frankfurter Str. 250, D-64293 Darmstadt, Germany
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Biomedicines 2018, 6(4), 101; https://doi.org/10.3390/biomedicines6040101
Received: 10 October 2018 / Revised: 24 October 2018 / Accepted: 26 October 2018 / Published: 1 November 2018
(This article belongs to the Special Issue Stem Cells and Cancer Therapeutics)
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Abstract

Breast cancer is the second leading cause of cancer deaths among women in the world. Treatment has been improved and, in combination with early detection, this has resulted in reduced mortality rates. Further improvement in therapy development is however warranted. This will be particularly important for certain sub-classes of breast cancer, such as triple-negative breast cancer, where currently no specific therapies are available. An important therapy development focus emerges from the notion that dysregulation of two major signaling pathways, Notch and Wnt signaling, are major drivers for breast cancer development. In this review, we discuss recent insights into the Notch and Wnt signaling pathways and into how they act synergistically both in normal development and cancer. We also discuss how dysregulation of the two pathways contributes to breast cancer and strategies to develop novel breast cancer therapies starting from a Notch and Wnt dysregulation perspective. View Full-Text
Keywords: breast cancer; cancer stem cell; tumor therapy; Notch signaling; Wnt signaling breast cancer; cancer stem cell; tumor therapy; Notch signaling; Wnt signaling
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Braune, E.-B.; Seshire, A.; Lendahl, U. Notch and Wnt Dysregulation and Its Relevance for Breast Cancer and Tumor Initiation. Biomedicines 2018, 6, 101.

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