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Biomedicines 2018, 6(3), 81; https://doi.org/10.3390/biomedicines6030081

Progress in Adenoviral Capsid-Display Vaccines

Janssen Infectious Diseases and Vaccines, Pharmaceutical Companies of Johnson and Johnson, 2301 CA Leiden, The Netherlands
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Received: 29 June 2018 / Revised: 20 July 2018 / Accepted: 23 July 2018 / Published: 26 July 2018
(This article belongs to the Special Issue Adenoviruses: From Virus to Medicine)
Full-Text   |   PDF [1019 KB, uploaded 26 July 2018]   |  

Abstract

Adenoviral vectored vaccines against infectious diseases are currently in clinical trials due to their capacity to induce potent antigen-specific B- and T-cell immune responses. Heterologous prime-boost vaccination with adenoviral vector and, for example, adjuvanted protein-based vaccines can further enhance antigen-specific immune responses. Although leading to potent immune responses, these heterologous prime-boost regimens may be complex and impact manufacturing costs limiting efficient implementation. Typically, adenoviral vectors are engineered to genetically encode a transgene in the E1 region and utilize the host cell machinery to express the encoded antigen and thereby induce immune responses. Similarly, adenoviral vectors can be engineered to display foreign immunogenic peptides on the capsid-surface by insertion of antigens in capsid proteins hexon, fiber and protein IX. The ability to use adenoviral vectors as antigen-display particles, with or without using the genetic vaccine function, greatly increases the versatility of the adenoviral vector for vaccine development. This review describes the application of adenoviral capsid antigen-display vaccine vectors by focusing on their distinct advantages and possible limitations in vaccine development. View Full-Text
Keywords: adenovirus; vaccine; adenovirus vector; capsid; capsid-display; hexon; fiber; penton; pIX adenovirus; vaccine; adenovirus vector; capsid; capsid-display; hexon; fiber; penton; pIX
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Vujadinovic, M.; Vellinga, J. Progress in Adenoviral Capsid-Display Vaccines. Biomedicines 2018, 6, 81.

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