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Biomedicines 2018, 6(1), 13; https://doi.org/10.3390/biomedicines6010013

The Role of Photodynamic Therapy in the Treatment of Vulvar Intraepithelial Neoplasia

1
Division of Melanoma, Soft Tissue Sarcomas and Rare Tumors, Istituto Europeo di Oncologia, Via G. Ripamonti 437, 20141 Milano, Italy
2
Preventive Gynecology Unit, Istituto Europeo di Oncologia, 20141 Milano, Italy
3
Unit of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, Policlinico Sant’Orsola-Malpighi, 40138 Bologna, Italy
4
Department of Dermatology, Policlinico Umberto I, Sapienza University of Rome, 00185 Rome, Italy
*
Author to whom correspondence should be addressed.
Received: 4 January 2018 / Revised: 25 January 2018 / Accepted: 30 January 2018 / Published: 2 February 2018
(This article belongs to the Special Issue Photodynamic Therapy in Cancer)
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Abstract

Background: vulvar intraepithelial neoplasia is a non-invasive precursor lesion found in 50–70% of patients affected by vulvar squamous cell carcinoma. In the past, radical surgery was the standard treatment for vulvar intraepithelial neoplasia, however, considering the psychological and physical morbidities related to extensive surgery, several less aggressive treatment modalities have been proposed since the late 1970s. Photodynamic therapy is an effective and safe treatment for cutaneous non-melanoma skin cancer, with favorable cosmetic outcomes. Methods: in the present paper, the results of selected studies on photodynamic therapy in the treatment of vulvar intraepithelial neoplasia are reported and discussed. Results: Overall, complete histological response rates ranged between 20% and 67% and symptom response rates ranged between 52% and 89% according to different studies and case series. Conclusions: the real benefit of photodynamic therapy in the setting of vulvar intraepithelial neoplasia lies in its ability to treat multi-focal disease with minimal tissue destruction, preservation of vulvar anatomy and excellent cosmetic outcomes. These properties explain why photodynamic therapy is an attractive option for vulvar intraepithelial neoplasia treatment. View Full-Text
Keywords: vulvar intraepithelial neoplasia; vulvar intraepithelial neoplasia (VIN); photodynamic therapy; PDT; vulvar intraepithelial neoplasia treatment; VIN treatment vulvar intraepithelial neoplasia; vulvar intraepithelial neoplasia (VIN); photodynamic therapy; PDT; vulvar intraepithelial neoplasia treatment; VIN treatment
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Tosti, G.; Iacobone, A.D.; Preti, E.P.; Vaccari, S.; Barisani, A.; Pennacchioli, E.; Cantisani, C. The Role of Photodynamic Therapy in the Treatment of Vulvar Intraepithelial Neoplasia. Biomedicines 2018, 6, 13.

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