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The Continued Promise and Many Disappointments of Oncolytic Virotherapy in Gastrointestinal Malignancies
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Biomedicines 2017, 5(1), 11;

Viroimmunotherapy for Colorectal Cancer: Clinical Studies

Beckman Research Institute, City of Hope National Medical Center, Duarte 91010, CA, USA
Author to whom correspondence should be addressed.
Academic Editors: Zong Sheng Guo and David L. Bartlett
Received: 1 February 2017 / Accepted: 2 March 2017 / Published: 10 March 2017
(This article belongs to the Special Issue Oncolytic Viruses as a Novel Form of Immunotherapy for Cancer)
Full-Text   |   PDF [679 KB, uploaded 11 March 2017]   |  


Colorectal cancer is a leading cause of cancer incidence and death. Therapies for those with unresectable or recurrent disease are not considered curative at present. More effective and less toxic therapies are desperately needed. Historically, the immune system was thought to be an enemy to oncolytic viral therapy. Thinking that oncolysis would be the only mechanism for cell death, oncolytic virologists theorized that immune clearance was a detriment to oncolysis. Recent advances in our understanding of the tumor microenvironment, and the interplay of tumor survival and a patient’s immune system have called into question our understanding of both arenas. It remains unclear what combination of restrictions or enhancements of innate and/or cell-mediated immunity can yield the highest likelihood of viral efficacy. This article reviews the variety of mechanisms explored for viruses such as immunotherapy for colorectal cancer. View Full-Text
Keywords: oncolytic virus; colorectal cancer; immunotherapy; viral gene therapy oncolytic virus; colorectal cancer; immunotherapy; viral gene therapy

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Chaurasiya, S.; Warner, S. Viroimmunotherapy for Colorectal Cancer: Clinical Studies. Biomedicines 2017, 5, 11.

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