Next Article in Journal / Special Issue
The Strategies to Homogenize PET/CT Metrics: The Case of Onco-Haematological Clinical Trials
Previous Article in Journal / Special Issue
Glioma FMISO PET/MR Imaging Concurrent with Antiangiogenic Therapy: Molecular Imaging as a Clinical Tool in the Burgeoning Era of Personalized Medicine
Open AccessFeature PaperReview

Personalized Dosimetry for Radionuclide Therapy Using Molecular Imaging Tools

Department of Medical Radiation Physics, Lund University, 221 85 Lund, Sweden
Author to whom correspondence should be addressed.
Academic Editor: Benjamin Franc
Biomedicines 2016, 4(4), 25;
Received: 12 September 2016 / Revised: 7 November 2016 / Accepted: 8 November 2016 / Published: 15 November 2016
(This article belongs to the Special Issue Molecular Imaging as a Tool for Personalized Medicine)
For treatment of systemic malignancies, when external radiation therapy is not applicable, radionuclide therapy can be an alternative. In this form of therapy, radionuclides are administered to the patient, often in a form where the radionuclide is labelled to a molecule that plays the active part in the localization of the tumor. Since the aim is to impart lethal damage to tumor cells while maintaining possible side-effects to normal tissues at tolerable levels, a proper and accurate personalized dosimetry should be a pre-requisite. In radionuclide therapy, there is a need to measure the distribution of the radiopharmaceutical in vivo, as well as its re-distribution over time, in order estimate the total energy released in radioactive decays and subsequent charged-particle interactions, governing the absorbed dose to different organs and tumors. Measurements are usually performed by molecular imaging, more specifically planar and SPECT (Single-Photon Emission Computed Tomography) imaging, combined with CT. This review describes the different parts in the dosimetry chain of radionuclide therapy. Emphasis is given to molecular imaging tools and the requirements for determining absorbed doses from quantitative planar and SPECT images. As example solutions to the different problems that need to be addressed in such a dosimetric chain, we describe our tool, Lundadose, which is a set of methods that we have developed for personalized dosimetry. View Full-Text
Keywords: dosimetry; radionuclide therapy; SPECT; reconstruction; quantification; Monte Carlo dosimetry; radionuclide therapy; SPECT; reconstruction; quantification; Monte Carlo
Show Figures

Figure 1

MDPI and ACS Style

Ljungberg, M.; Sjögreen Gleisner, K. Personalized Dosimetry for Radionuclide Therapy Using Molecular Imaging Tools. Biomedicines 2016, 4, 25.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop