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Open AccessArticle

High Levels of IL-10 and CD4+CD25hi+ Treg Cells in Endemic Burkitt’s Lymphoma Patients

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Department of Animal Biology and Conservation Science, College of Basic and Applied Sciences, University of Ghana, Legon, Accra, Ghana
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Immunology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Accra, Ghana
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Department of Child Health, School of Medicine and Dentistry, College of Health Sciences, University of Ghana, Accra, Ghana
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Division of Immunization, Vaccines & Emergencies (IVE), WHO Regional Office for Africa, Cité Djoué, PO Box 06 Brazzaville, Congo Republic
*
Author to whom correspondence should be addressed.
Academic Editor: Kenneth Cornetta
Biomedicines 2015, 3(3), 224-236; https://doi.org/10.3390/biomedicines3030224
Received: 29 June 2015 / Revised: 17 July 2015 / Accepted: 28 July 2015 / Published: 4 August 2015
Background: The interplay between Epstein-Barr virus infection, malaria, and endemic Burkitt’s Lymphoma is not well understood. Reports show diminished EBV-specific Th1 responses in children living in malaria endemic areas and deficiency of EBNA1-specific IFN-γ T cell responses in children with endemic Burkitt’s Lymphoma (eBL). This study, therefore, examined some factors involved in the loss of EBNA-1-specific T cell responses in eBL. Methods: T-cell subset frequencies, activation, and IFN-γ- or IL-4-specific responses were analyzed by flow-cytometry. Plasma cytokine levels were measured by ELISA. Results: CD4+ and CD8+ cells in age- and sex-matched healthy controls (n = 3) expressed more IFN-γ in response to all immunostimulants than in pediatric endemic BL (eBL) patients (n = 4). In healthy controls, IFN-γ expression was higher than IL-4 expression, whereas in eBL patients the expression of IL-4 by CD4+ cells to EBNA-1 was slightly higher than IFN-γ. Moreover, the blood levels of TNF-α was significantly lower (p = 0.004) while IL-10 was significantly higher (p = 0.038), in eBL patients (n = 21) compared to controls (n = 16). Additionally, the frequency of CD4+CD25hi+ T cells was higher in both age-matched acute uncomplicated malaria (n = 26) and eBL (n = 14) patients compared to healthy controls (n = 19; p = 0.000 and p = 0.027, respectively). Conclusion: The data suggest that reduced Th1 response in eBL might be due to increased levels of IL-10 and T reg cells. View Full-Text
Keywords: Burkitt’s lymphoma; malaria; EBNA1; Th2; Treg cells Burkitt’s lymphoma; malaria; EBNA1; Th2; Treg cells
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Futagbi, G.; Gyan, B.; Nunoo, H.; Tetteh, J.K.; Welbeck, J.E.; Renner, L.A.; Ofori, M.; Dodoo, D.; Edoh, D.A.; Akanmori, B.D. High Levels of IL-10 and CD4+CD25hi+ Treg Cells in Endemic Burkitt’s Lymphoma Patients. Biomedicines 2015, 3, 224-236.

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