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Volume 14
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10.3390/biomedicines14020466
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Article

An Implantable Loop Recorder in the Diagnosis of Cardiac Arrhythmias: The Importance of Drug Treatment in Predicting Pacemaker Requirement

by
Jelena Vučković-Filipović
1,2,
Vladimir Ignjatović
1,2,*,
Isidora Stanković
2,
Neda Ćićarić
2,3,
Vesna Ignjatović
4,
Goran Davidović
1,2,
Vladimir Miloradović
1,2,
Violeta Irić-Ćupić
1,2,
Ivan Simić
1,2 and
Natasa Djordjevic
3
1
Department of Internal Medicine, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia
2
Clinic for Cardiology, University Clinical Center Kragujevac, 34000 Kragujevac, Serbia
3
Department of Pharmacology and Toxicology, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia
4
Department of Nuclear Medicine, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia
*
Author to whom correspondence should be addressed.
Biomedicines 2026, 14(2), 466; https://doi.org/10.3390/biomedicines14020466
Submission received: 19 January 2026 / Revised: 16 February 2026 / Accepted: 17 February 2026 / Published: 19 February 2026
(This article belongs to the Special Issue Cardiac Arrhythmias: Technological Frontiers, Therapeutic Approaches and Future Directions)
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Abstract

Background: An implantable loop recorder (ILR) represents the gold standard in the diagnosis of cardiac arrhythmias in patients with neurological or cardiac symptoms. Our study aimed to determine the real-world diagnostic effectiveness of ILRs in detecting arrhythmias requiring permanent pacemaker implantation. Methods: The study enrolled and followed up for two years 62 ILR recipients from the Cardiology Clinic of the Clinical Center Kragujevac, Serbia. Results: The most common indication for pacemaker implantation was pauses in cardiac activity (83%). The use of oral anticoagulants (OR: 11.80; 95% CI: 1.76, 79.4), ACE inhibitors or AT receptor blockers (OR: 3.87; 95% CI: 1.21, 12.35), and diuretics (OR: 5.29; 95% CI: 1.55, 18.04) had a statistically significant impact on the detection of pacemaker-requiring arrhythmias by an ILR. After adjustment for other factors of influence, oral anticoagulants (OR: 7.82; 95% CI: 1.08, 56.9) and diuretics (OR: 3.68; 95% CI: 1.04, 13.00) remained significant in predicting pacemaker requirement in ILR recipients. Conclusions: An ILR represents an effective diagnostic approach in detecting cardiac arrhythmias requiring permanent pacemaker implantation, especially in patients treated with oral anticoagulants or diuretics.
Keywords: implantable loop recorder; syncope; cardiac arrhythmia; bradyarrhythmia; pacemaker; oral anticoagulants; diuretics implantable loop recorder; syncope; cardiac arrhythmia; bradyarrhythmia; pacemaker; oral anticoagulants; diuretics

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MDPI and ACS Style

Vučković-Filipović, J.; Ignjatović, V.; Stanković, I.; Ćićarić, N.; Ignjatović, V.; Davidović, G.; Miloradović, V.; Irić-Ćupić, V.; Simić, I.; Djordjevic, N. An Implantable Loop Recorder in the Diagnosis of Cardiac Arrhythmias: The Importance of Drug Treatment in Predicting Pacemaker Requirement. Biomedicines 2026, 14, 466. https://doi.org/10.3390/biomedicines14020466

AMA Style

Vučković-Filipović J, Ignjatović V, Stanković I, Ćićarić N, Ignjatović V, Davidović G, Miloradović V, Irić-Ćupić V, Simić I, Djordjevic N. An Implantable Loop Recorder in the Diagnosis of Cardiac Arrhythmias: The Importance of Drug Treatment in Predicting Pacemaker Requirement. Biomedicines. 2026; 14(2):466. https://doi.org/10.3390/biomedicines14020466

Chicago/Turabian Style

Vučković-Filipović, Jelena, Vladimir Ignjatović, Isidora Stanković, Neda Ćićarić, Vesna Ignjatović, Goran Davidović, Vladimir Miloradović, Violeta Irić-Ćupić, Ivan Simić, and Natasa Djordjevic. 2026. "An Implantable Loop Recorder in the Diagnosis of Cardiac Arrhythmias: The Importance of Drug Treatment in Predicting Pacemaker Requirement" Biomedicines 14, no. 2: 466. https://doi.org/10.3390/biomedicines14020466

APA Style

Vučković-Filipović, J., Ignjatović, V., Stanković, I., Ćićarić, N., Ignjatović, V., Davidović, G., Miloradović, V., Irić-Ćupić, V., Simić, I., & Djordjevic, N. (2026). An Implantable Loop Recorder in the Diagnosis of Cardiac Arrhythmias: The Importance of Drug Treatment in Predicting Pacemaker Requirement. Biomedicines, 14(2), 466. https://doi.org/10.3390/biomedicines14020466

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