Atherogenic Index of Plasma Predicts Futile Reperfusion and Early Deterioration After Successful Recanalization: A Multicenter Study of EVT-Treated LAA Stroke
Abstract
1. Introduction
2. Methods
2.1. Study Population
2.2. Data Collection and Definition of Parameters
2.3. Statistical Analysis
3. Results
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Data Availability Statement
Conflicts of Interest
References
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Q1 (n = 101) | Q2 (n = 102) | Q3 (n = 101) | Q4 (n = 102) | p-Value | |
---|---|---|---|---|---|
Age, year (SD) | 69.2 (1.4) | 69.7 (12.9) | 66.2 (14.4) | 66.6 (12.7) | 0.15 |
Male, % (SD) | 61 (60.4) | 62 (60.8) | 67 (66.3) | 58 (56.9) | 0.58 |
BMI, kg/cm2 (IQR) | 23 (21–25) | 23 (21–25) | 23 (22–26) | 23 (22–26) | 0.14 |
Initial NIHSS, score (IQR) | 14 (9–18) | 14 (10–17) | 14 (9–18) | 13 (8–17) | 0.28 |
Time Interval from stroke onset to arrival, h (IQR) | 1.38 (0.73–3.97) | 1.29 (0.63–4.06) | 1.92 (0.96–4.87) | 1.46 (0.67–3.70) | 0.08 |
Time Interval from arrival to groin puncture, min (IQR) | 116 (90–144) | 105 (76–141) | 104 (77–147) | 106 (81–153) | 0.64 |
Prior stroke, % (SD) | 20 (19.8) | 26 (25.5) | 22 (21.8) | 17 (16.7) | 0.48 |
Hypertension, % (SD) | 61 (60.4) | 61 (59.8) | 54 (53.5) | 61 (59.8) | 0.72 |
Diabetes mellitus, % (SD) | 22 (21.8) | 22 (21.6) | 28 (27.7) | 36 (35.3) | 0.09 |
Hyperlipidemia, % (SD) | 26 (25.7) | 17 (16.7) | 19 (18.8) | 22 (21.6) | 0.42 |
Current smoking, % (SD) | 9 (8.9) | 3 (2.9) | 14 (13.9) | 22 (21.6) | <0.001 |
Prior antithrombotics, % (SD) | 18 (17.8) | 25 (24.5) | 25 (24.8) | 25 (24.5) | 0.58 |
Reperfusion therapy, % (SD) | 0.14 | ||||
EVT only | 60 (59.4) | 44 (43.1) | 51 (50.5) | 50 (49.0) | |
IVT + EVT | 41 (40.6) | 58 (56.9) | 50 (49.5) | 52 (51.0) | |
ASPECTS, score (IQR) | 8 (7–9) | 8 (7–9) | 8 (7–9) | 8 (7–9) | |
Collateral status, % (SD) | 0.75 | ||||
Good | 58 (57.4) | 61 (59.8) | 60 (59.4) | 66 (64.70) | |
Intermediate | 43 (42.6) | 41 (4.02) | 41 (40.6) | 36 (35.3) | |
Medications at discharge | |||||
Antiplatelet agents | 92 (91.1) | 84 (82.4) | 82 (81.2) | 83 (81.5) | 0.17 |
Antihypertensive agents | 89 (88.1) | 85 (83.3) | 82 (81.2) | 80 (78.4) | 0.31 |
Antidiabetic agents | 50 (49.5) | 44 (43.1) | 46 (45.5) | 47 (46.1) | 0.85 |
Statin | 84 (83.2) | 78 (76.5) | 74 (73.3) | 81 (79.4) | 0.37 |
Platelet count, ×1000/μL (SD) | 214 (23.1) | 148 (26.6) | 148 (24.0) | 148 (25.6) | 0.18 |
Creatinine, mg/dL (SD) | 1.08 (0.69) | 1.18 (1.64) | 1.03 (0.29) | 1.11 (0.81) | 0.76 |
LDL, mmol (SD) | 2.2 (0.8) | 2.6 (0.9) | 2.8 (0.9) | 2.7 (1.1) | <0.001 |
Glycated hemoglobin, % (SD) | 5.9 (1.1) | 5.9 (0.9) | 6.3 (1.4) | 6.5 (1.6) | 0.002 |
CRP, mg/dL (SD) | 9.4 (16.9) | 9.9 (12.9) | 13.4 (28.6) | 16.1 (31.1) | 0.15 |
Initial glucose, mg/dL (SD) | 143 (62.1) | 139 (51.9) | 154 (66.3) | 154 (66.3) | 0.32 |
SBP, mmHg (SD) | 144 (23.1) | 148 (26.6) | 148 (25.6) | 147 (24.8) | 0.47 |
FR | END | Stroke Progression | Stroke Recurrence | SHT | ||||||
---|---|---|---|---|---|---|---|---|---|---|
OR * | 95% CI | OR * | 95% CI | OR * | 95% CI | OR * | 95% CI | OR * | 95% CI | |
AIP in Quartiles | ||||||||||
Q1 | reference | reference | reference | reference | reference | |||||
Q2 | 1.48 | 0.80–2.74 | 2.96 | 1.08–8.11 | 2.78 | 0.71–10.92 | 1.52 | 0.23–10.09 | 4.87 | 0.52–37.45 |
Q3 | 2.74 | 1.43–5.26 | 7.25 | 2.75–19.14 | 5.92 | 1.61–21.87 | 1.38 | 0.22–8.78 | 16.01 | 1.90–134.96 |
Q4 | 4.31 | 2.16–8.61 | 9.08 | 3.48–23.67 | 6.34 | 1.73–23.27 | 4.62 | 0.80–25.02 | 11.87 | 1.43–98.20 |
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Sohn, J.-H.; In, Y.-H.; Kim, C.; Sung, J.H.; Lee, M.; Kim, Y.; Lee, J.J.; Lee, S.-H. Atherogenic Index of Plasma Predicts Futile Reperfusion and Early Deterioration After Successful Recanalization: A Multicenter Study of EVT-Treated LAA Stroke. Biomedicines 2025, 13, 2127. https://doi.org/10.3390/biomedicines13092127
Sohn J-H, In Y-H, Kim C, Sung JH, Lee M, Kim Y, Lee JJ, Lee S-H. Atherogenic Index of Plasma Predicts Futile Reperfusion and Early Deterioration After Successful Recanalization: A Multicenter Study of EVT-Treated LAA Stroke. Biomedicines. 2025; 13(9):2127. https://doi.org/10.3390/biomedicines13092127
Chicago/Turabian StyleSohn, Jong-Hee, Yong-Ho In, Chulho Kim, Joo Hye Sung, Minwoo Lee, Yerim Kim, Jae Jun Lee, and Sang-Hwa Lee. 2025. "Atherogenic Index of Plasma Predicts Futile Reperfusion and Early Deterioration After Successful Recanalization: A Multicenter Study of EVT-Treated LAA Stroke" Biomedicines 13, no. 9: 2127. https://doi.org/10.3390/biomedicines13092127
APA StyleSohn, J.-H., In, Y.-H., Kim, C., Sung, J. H., Lee, M., Kim, Y., Lee, J. J., & Lee, S.-H. (2025). Atherogenic Index of Plasma Predicts Futile Reperfusion and Early Deterioration After Successful Recanalization: A Multicenter Study of EVT-Treated LAA Stroke. Biomedicines, 13(9), 2127. https://doi.org/10.3390/biomedicines13092127