Relationship Between Radiological Features of Primary Empty or Primary Partial Empty Sella and Pituitary Hormone Levels
Abstract
1. Introduction
2. Material and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Variable | Patients Without Hormonal Disorders n = 37 | Patients with Hormonal Disorders n = 6 | p-Value |
---|---|---|---|
Age [years] | 59.432 ± 14.041 | 44.167 ± 12.254 | 0.021 |
Sex [M] | 9 (2.324%) | 0 (0%) | 0.187 |
Body weight [kg] | 79.697 ± 13.462 | 67.583 ± 10.414 | 0.034 |
BMI [kg/m2] | 28.096 ± 4.567 | 25.45 ± 3.169 | 0.045 |
Overweight and obesity | 27 (72.973%) | 3 (50%) | 0.271 |
Waist circumference [cm] | 95.125 ± 11.284 | 79.833 ± 15.943 | 0.022 |
Arterial hypertension | 16 (43.243%) | 1 (16.667%) | 0.16 |
Variable | Patients Without Hormonal Disorders n = 37 | Patients with Hormonal Disorders n = 6 | p-Value | ||
---|---|---|---|---|---|
Median (Min–Max) | Mean ± SD | Median (Min–Max) | Mean ± SD | ||
Specific gravity of urine [g/mL] | 1.016 (1.007–1.04) | 1.017 ± 0.007 | 1.013 (1.006–1.028) | 1.016 ± 0.009 | 0.663 |
Serum sodium [mmol/L] | 142 (128–145) | 141 ± 3.04 | 137.50 (136–141) | 138 ± 1.79 | 0.005 |
Serum potassium [mmol/L] | 4.55 (3.78–5.39) | 4.54 ± 0.39 | 4.13 (3.69–4.49) | 4.12 ± 0.29 | 0.016 |
Serum osmolality [mOsm/kg] | 291 (278–313) | 290.87 ± 6.79 | 287 (282–293) | 287.33 ± 3.67 | 0.171 |
Urine osmolality [mOsm/kg] | 539.50 (251–956) | 571.75 ± 203.21 | 440.5 (258–957) | 558.33 ± 304.79 | 0.787 |
TSH [µIU/mL] | 1.95 (0.27–4.08) | 1.959 ± 0.97 | 2.02 (0.95–2.82) | 1.90 ± 0.74 | 0.899 |
fT3 [pg/mL] | 3.06 (2.16–3.82) | 3.10 ± 0.39 | 2.75 (2.34–3.58) | 2.83 ± 0.43 | 0.109 |
fT4 [ng/dL] | 1.26 (1.02–1.70) | 1.27 ± 0.162 | 1.10 (0.90–1.33) | 1.11 ± 0.168 | 0.081 |
Prolactin [ng/mL] | 11.00 (4.9–20.8) | 11.86 ± 5.21 | 15.15 (3.20–52.60) | 22.08 ± 18.69 | 0.326 |
Cortisol at 8 a.m. [µg/dL] | 14.30 (6.1–24.5) | 13.68 ± 3.63 | 11.6 (8.90–24.30) | 14.73 ± 6.56 | 0.746 |
ACTH at 8 a.m. [pg/mL] | 22.5 (7.3–87.2) | 25.82 ± 16.29 | 15.8 (2.30–28.90) | 16.08 ± 9.04 | 0.136 |
Growth hormone [ng/mL] | 0.44 (0.05–17.10) | 1.32 ± 2.99 | 0.45 (0.17–8.96) | 2.17 ± 3.47 | 0.472 |
IGF-1 [ng/mL] | 135.50 (61.33–253.50) | 140.84 ± 46.41 | 188.70 (82.65–350.80) | 195.09 ± 94.43 | 0.166 |
Variable | Mean | SD | Median | Minimum | Maximum |
---|---|---|---|---|---|
ACTH [pg/mL] (n = 6) | 16.067 | 9.041 | 15.800 | 2.300 | 28.900 |
ACTH [pg/mL] in patients with secondary adrenocortical insufficiency on glucocorticoid replacement with Hydrocortisonum (n = 3) | 10.667 | 7.786 | 12.000 | 2.300 | 17.700 |
Serum cortisol [µg/dL] | 14.733 | 6.563 | 11.600 | 8.900 | 24.300 |
Serum cortisol [µg/dL] in patients with secondary adrenocortical insufficiency on glucocorticoid replacement with Hydrocortisonum (n = 3) | 18.300 | 8.24 | 21.700 | 8.900 | 24.300 |
Serum prolactin [ng/mL] (n = 6) | 22.083 | 18.691 | 15.150 | 3.200 | 52.600 |
Serum prolactin [ng/mL] in patients with hyperprolactinemia (n = 4) | 26.700 | 22.154 | 25.500 | 3.200 | 52.600 |
Serum prolactin [ng/mL] in patients with hyperprolactinemia receiving dopamine receptor agonists (n = 2) | 8.800 | 7.919 | 8.800 | 3.200 | 14.400 |
Serum prolactin [ng/mL] in patients with hyperprolactinemia receiving no dopamine receptor agonists (n = 2) | 44.600 | 11.314 | 44.600 | 36.600 | 52.600 |
TSH [µIU/mL] | 1.904 | 0.741 | 2.020 | 0.952 | 2.820 |
fT3 [pg/mL] | 2.833 | 0.426 | 2.745 | 2.340 | 3.580 |
fT4 [ng/dL] | 1.110 | 0.168 | 1.100 | 0.900 | 1.330 |
Growth hormone [ng/mL] | 2.168 | 3.465 | 0.450 | 0.170 | 8.960 |
IGF-1 [ng/mL] | 195.092 | 94.434 | 188.700 | 82.650 | 350.800 |
Variable | Patients Without Hormonal Disorders n = 37 | Patients with Hormonal Disorders n = 6 | p-Value | ||
---|---|---|---|---|---|
Median (Min–Max) | Mean ± SD | Median (Min–Max) | Mean ± SD | ||
Pituitary AP diameter [mm] | 12.00 (7.50–17.10) | 12.40 ± 2.03 | 12.00(10.00–13.30) | 12.00 ± 1.38 | 0.659 |
Pituitary RL diameter [mm] | 16.00 (5.00–25.00) | 15.95 ± 3.27 | 16.25 (14.40–20.00) | 16.80 ± 2.39 | 0.516 |
Pituitary CC diameter [mm] | 2.80 (0.80–5.00) | 2.97 ± 1.06 | 2.90 (1.40–4.50) | 3.05 ± 1.093 | 0.752 |
Pituitary volume [mm3] | 276.12 (62.40–536.30) | 284.14 ± 105.12 | 299.55 (194.194–368.00) | 290.29 ± 60.05 | 0.739 |
Sella turcica—AP diameter [mm] | 12.00 (7.50–17.10) | 12.51 ± 2.08 | 12.50 (10.00–14.30) | 12.38 ± 1.15 | 0.902 |
Sella turcica—RL diameter [mm] | 16.00 (5.00–25.00) | 15.95 ± 3.27 | 16.25 (14.40–20.00) | 16.80 ± 2.39 | 0.516 |
Sella turcica—bony—CC diameter [mm] | 10.40 (7.30–17.40) | 11.25 ± 2.53 | 10.40 (9.50–13.30) | 10.68 ± 1.43 | 0.833 |
Sella turcica—diaphragma sellae—CC diameter [mm] | 7.40 (5.50–15.70) | 8.20 ± 2.46 | 7.90 (6.50–9.70) | 7.97 ± 1.26 | 0.699 |
Bony sellar volume [mm3] | 976.19 (140.63–1683.71) | 1186.41 ± 591.43 | 1099.03 (792.00–1498.07) | 1110.28 ± 249,81 | 0.661 |
Sellar volume—diaphragma sellae [mm3] | 665.63 (116.25–2316.99) | 874.48 ± 506.25 | 769.97 (597.60–1248.39) | 831.69 ± 231.16 | 0.451 |
Pituitary volume expressed as a percentage of sellar volume [%] | 28.79 (6.02–66.67) | 28.15 ± 12.93 | 27.25 (12.96–40.91) | 28.14 ± 10.91 | 0.986 |
Pituitary height expressed as a percentage of bony sella height [%] | 28.79 (6.02–66.67) | 28.35 ± 12.94 | 28.95 (12.96–40.91) | 28.93 ± 10.74 | 0.875 |
Pituitary height expressed as a percentage of sella height—diaphragma sellae [%] | 39.79 (9.09–80.65) | 40.08 ± 19.25 | 41.43 (15.56–54.22) | 39.31 ± 14.84 | 0.986 |
Right optic nerve sheath diameter [mm] | 4.65 (3.80–5.80) | 4.71 ± 0.44 | 4.75 (4.40–5.30) | 4.77 ± 0.33 | 0.793 |
Left optic nerve sheath diameter [mm] | 4.60 (3.70–6.30) | 4.56 ± 0.51 | 4.5 (3.90–5.30) | 4.57 ± 0.47 | 0.930 |
VARIABLE | N (%) | N (%) | p-value | ||
Empty sella—with the pituitary CC diameter less than 2 mm | 8 (21.62%) | 1 (16.67%) | 0.804 | ||
Empty sella—with the pituitary CC diameter less than 3 mm | 19 (51.35%) | 4 (66.67%) | 0.503 | ||
Pituitary stalk displacement | 21 (56.76%) | 3 (50.00%) | 0.757 | ||
Enlarged cerebrospinal fluid spaces | 10 (27.03%) | 1 (16.67%) | 0.589 |
Variable | Hormonal Disorders OR (95% CI) p-Value | |
---|---|---|
Multivariate Logistic Regression | Univariate Logistic Regression | |
Sex | 0.00 (0.00–0.00), p = 0.998 | 0.00 (0.00–0.00), p = 0.997 |
Age | 0.898 (0.798–1.01), p = 0.073 | 0.916 (0.844–0.993), p = 0.034 |
Empty sella [2 mm] | 1.439 (0.008–297.121), p = 0.882 | 0.725 (0.074–7.126), p = 0.783 |
Empty sella [3 mm] | 3.725 (0.012–1131.502), p = 0.652 | 1.895 (0.308–11.644), p = 0.49 |
Pituitary—craniocaudal diameter [mm] | 10.380 (0.072–1495.711), p = 0.356 | 1.073 (0.469–2.454), p = 0.8668 |
Pituitary volume [mm3] | 0.993 (0.964–1.024), p = 0.668 | 1.001 (0.992–1.009), p = 0.887 |
Sellar volume [mm3] | 0.998 (0.992–1.004), p = 0.506 | 1 (0.998–1.001), p = 0.7531 |
Pituitary volume expressed as percentage of sellar volume(bony sella) | 0.296 (0.033–2.639), p = 0.276 | 1 (0.933–1.072), p = 0.999 |
Pituitary height expressed as percentage of sellar height (bony sella) | 2.816 (0.293–27.105), p = 0.37 | 1.004 (0.937–1.076), p = 0.916 |
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Kałuża, B.; Furmanek, M.; Domański, J.; Żuk-Łapan, A.; Babula, E.; Poprawa, I.; Walecki, J.; Franek, E. Relationship Between Radiological Features of Primary Empty or Primary Partial Empty Sella and Pituitary Hormone Levels. Biomedicines 2025, 13, 722. https://doi.org/10.3390/biomedicines13030722
Kałuża B, Furmanek M, Domański J, Żuk-Łapan A, Babula E, Poprawa I, Walecki J, Franek E. Relationship Between Radiological Features of Primary Empty or Primary Partial Empty Sella and Pituitary Hormone Levels. Biomedicines. 2025; 13(3):722. https://doi.org/10.3390/biomedicines13030722
Chicago/Turabian StyleKałuża, Bernadetta, Mariusz Furmanek, Jan Domański, Aleksandra Żuk-Łapan, Emilia Babula, Iga Poprawa, Jerzy Walecki, and Edward Franek. 2025. "Relationship Between Radiological Features of Primary Empty or Primary Partial Empty Sella and Pituitary Hormone Levels" Biomedicines 13, no. 3: 722. https://doi.org/10.3390/biomedicines13030722
APA StyleKałuża, B., Furmanek, M., Domański, J., Żuk-Łapan, A., Babula, E., Poprawa, I., Walecki, J., & Franek, E. (2025). Relationship Between Radiological Features of Primary Empty or Primary Partial Empty Sella and Pituitary Hormone Levels. Biomedicines, 13(3), 722. https://doi.org/10.3390/biomedicines13030722