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Article

Preventive and Therapeutic Effects of Hydrogen-Generating Si-Based Agent on Pressure Ulcers in Mice

1
Department of Plastic Surgery, The University of Osaka Graduate School of Medicine, Osaka 565-0871, Japan
2
SANKEN, The University of Osaka, Osaka 567-0047, Japan
3
Department of Plastic and Reconstructive Surgery, Kindai University Faculty of Medicine, Osaka 589-8511, Japan
*
Author to whom correspondence should be addressed.
Biomedicines 2025, 13(10), 2475; https://doi.org/10.3390/biomedicines13102475 (registering DOI)
Submission received: 5 September 2025 / Revised: 8 October 2025 / Accepted: 9 October 2025 / Published: 11 October 2025
(This article belongs to the Topic Oxidative Stress and Inflammation, 3rd Edition)

Abstract

Objectives: As a known antioxidant, hydrogen has been useful for treating pressure ulcers. However, conventional methods of hydrogen administration have limitations with regard to dosage and continuity of hydrogen intake. This study evaluated the efficacy of a novel Si-containing agent that can generate substantial quantities of hydrogen to treat pressure ulcers in an in vivo mouse model. Methods: The back skin and subcutaneous tissue of mice were compressed with magnets for 12 h. Changes in the ulcer area after release of compression, histological findings, degree of apoptosis, and expression levels for oxidative stress markers and inflammation-related cytokines were compared between mice fed a normal diet (control group) and those fed a 2.5 wt% Si-based diet (Si group). Results: The Si group had a significantly smaller ulcer area and shorter healing period than the control group. Moreover, inflammatory responses, apoptotic activity, and oxidative stress within the ulcer tissue were suppressed significantly in the Si group. Conclusions: Oral intake of the Si-based agent can potentially treat and prevent pressure ulcers by regulating apoptosis, oxidative stress, and inflammatory responses.
Keywords: pressure ulcer; hydrogen; oxidative stress; inflammation; apoptosis pressure ulcer; hydrogen; oxidative stress; inflammation; apoptosis

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MDPI and ACS Style

Otani, N.; Oue, T.; Kobayashi, Y.; Kobayashi, H.; Tomita, K.; Kubo, T. Preventive and Therapeutic Effects of Hydrogen-Generating Si-Based Agent on Pressure Ulcers in Mice. Biomedicines 2025, 13, 2475. https://doi.org/10.3390/biomedicines13102475

AMA Style

Otani N, Oue T, Kobayashi Y, Kobayashi H, Tomita K, Kubo T. Preventive and Therapeutic Effects of Hydrogen-Generating Si-Based Agent on Pressure Ulcers in Mice. Biomedicines. 2025; 13(10):2475. https://doi.org/10.3390/biomedicines13102475

Chicago/Turabian Style

Otani, Naoya, Takaki Oue, Yuki Kobayashi, Hikaru Kobayashi, Koichi Tomita, and Tateki Kubo. 2025. "Preventive and Therapeutic Effects of Hydrogen-Generating Si-Based Agent on Pressure Ulcers in Mice" Biomedicines 13, no. 10: 2475. https://doi.org/10.3390/biomedicines13102475

APA Style

Otani, N., Oue, T., Kobayashi, Y., Kobayashi, H., Tomita, K., & Kubo, T. (2025). Preventive and Therapeutic Effects of Hydrogen-Generating Si-Based Agent on Pressure Ulcers in Mice. Biomedicines, 13(10), 2475. https://doi.org/10.3390/biomedicines13102475

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