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Volume 12
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10.3390/biomedicines12081670
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Review

Emerging Therapeutic Targets for Acute Coronary Syndromes: Novel Advancements and Future Directions

by
Andreas Mitsis
1,*,
Michael Myrianthefs
1,
Stefanos Sokratous
1,
Georgia Karmioti
1,
Michaela Kyriakou
1,
Michail Drakomathioulakis
1,
Stergios Tzikas
2,
Nikolaos P. E. Kadoglou
3,
Efstratios Karagiannidis
4,
Athina Nasoufidou
4,
Nikolaos Fragakis
4,
Antonios Ziakas
5 and
George Kassimis
4
1
Cardiology Department, Nicosia General Hospital, State Health Services Organization, Nicosia 2029, Cyprus
2
Third Department of Cardiology, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece
3
Medical School, University of Cyprus, Nicosia 2115, Cyprus
4
Second Department of Cardiology, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece
5
First Department of Cardiology, AHEPA University Hospital, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece
*
Author to whom correspondence should be addressed.
Biomedicines 2024, 12(8), 1670; https://doi.org/10.3390/biomedicines12081670
Submission received: 9 July 2024 / Revised: 21 July 2024 / Accepted: 24 July 2024 / Published: 26 July 2024
(This article belongs to the Special Issue Exploring Acute Coronary Syndrome: Insights from Basic and Clinical Research)
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Abstract

Acute coronary syndrome (ACS) remains a major cause of morbidity and mortality worldwide, requiring ongoing efforts to identify novel therapeutic targets to improve patient outcomes. This manuscript reviews promising therapeutic targets for ACS identified through preclinical research, including novel antiplatelet agents, anti-inflammatory drugs, and agents targeting plaque stabilization. Preclinical studies have expounded these agents’ efficacy and safety profiles in mitigating key pathophysiological processes underlying ACS, such as platelet activation, inflammation, and plaque instability. Furthermore, ongoing clinical trials are evaluating the efficacy and safety of these agents in ACS patients, with potential implications for optimizing ACS management. Challenges associated with translating preclinical findings into clinical practice, including patient heterogeneity and trial design considerations, are also discussed. Overall, the exploration of emerging therapeutic targets offers promising avenues for advancing ACS treatment strategies and improving patient outcomes.
Keywords: acute coronary syndrome; antiplatelet agents; anti-inflammatory drugs; cardiovascular biomarkers; cardiovascular inflammation; clinical trials; plaque stabilization acute coronary syndrome; antiplatelet agents; anti-inflammatory drugs; cardiovascular biomarkers; cardiovascular inflammation; clinical trials; plaque stabilization

Share and Cite

MDPI and ACS Style

Mitsis, A.; Myrianthefs, M.; Sokratous, S.; Karmioti, G.; Kyriakou, M.; Drakomathioulakis, M.; Tzikas, S.; Kadoglou, N.P.E.; Karagiannidis, E.; Nasoufidou, A.; et al. Emerging Therapeutic Targets for Acute Coronary Syndromes: Novel Advancements and Future Directions. Biomedicines 2024, 12, 1670. https://doi.org/10.3390/biomedicines12081670

AMA Style

Mitsis A, Myrianthefs M, Sokratous S, Karmioti G, Kyriakou M, Drakomathioulakis M, Tzikas S, Kadoglou NPE, Karagiannidis E, Nasoufidou A, et al. Emerging Therapeutic Targets for Acute Coronary Syndromes: Novel Advancements and Future Directions. Biomedicines. 2024; 12(8):1670. https://doi.org/10.3390/biomedicines12081670

Chicago/Turabian Style

Mitsis, Andreas, Michael Myrianthefs, Stefanos Sokratous, Georgia Karmioti, Michaela Kyriakou, Michail Drakomathioulakis, Stergios Tzikas, Nikolaos P. E. Kadoglou, Efstratios Karagiannidis, Athina Nasoufidou, and et al. 2024. "Emerging Therapeutic Targets for Acute Coronary Syndromes: Novel Advancements and Future Directions" Biomedicines 12, no. 8: 1670. https://doi.org/10.3390/biomedicines12081670

APA Style

Mitsis, A., Myrianthefs, M., Sokratous, S., Karmioti, G., Kyriakou, M., Drakomathioulakis, M., Tzikas, S., Kadoglou, N. P. E., Karagiannidis, E., Nasoufidou, A., Fragakis, N., Ziakas, A., & Kassimis, G. (2024). Emerging Therapeutic Targets for Acute Coronary Syndromes: Novel Advancements and Future Directions. Biomedicines, 12(8), 1670. https://doi.org/10.3390/biomedicines12081670

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