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Volume 12
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10.3390/biomedicines12071599
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Article

Evaluation of Patellar Tendon Structural Changes following Biological Treatments: Secondary Analysis of Double-Blinded Clinical Trial of Bone Marrow Mesenchymal Stromal Cells and Leukocyte-Poor Platelet-Rich Plasma

by
Silvia Ortega-Cebrián
1,2,*,
Robert Soler-Rich
3,
Lluis Orozco
3 and
Gil Rodas
2,4
1
Physiotherapy Department, Facultat Fisioteràpia, Universitat Internacional de Catalunya (UIC), Carrer Josep Trueta, Sant Cugat de Vallès, 08017 Barcelona, Spain
2
Medical Department of Football Club Barcelona (FIFA Medical Center of Excellence), Barça Innovation Hub of Football Club Barcelona, 08970 Barcelona, Spain
3
Institut de Teràpia Regenerativa Tissular, Centro Médico Teknon, 08022 Barcelona, Spain
4
Sports and Exercise Medicine Unit, Hospital Clinic and Sant Joan de Déu, 08029 Barcelona, Spain
*
Author to whom correspondence should be addressed.
Biomedicines 2024, 12(7), 1599; https://doi.org/10.3390/biomedicines12071599
Submission received: 4 June 2024 / Revised: 11 July 2024 / Accepted: 15 July 2024 / Published: 18 July 2024
(This article belongs to the Special Issue Recent Advances in Arthritis and Tendinopathy)
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Abstract

Objective quantification of tendon structural changes through imaging is only achieved by evaluating tendon structure using ultrasound tissue characterization (UTC) technology. This study compares the effects of bone marrow mesenchymal stromal cells (BM-MSC) and leukocyte-poor platelet-rich plasma (Lp-PRP) on tendon structure and clinical outcomes in male patients with patellar tendinopathy measured with UTC at 3, 6, and 12 months after treatment. This is a double-blinded clinical trial with a randomized active control study with 20 male patients diagnosed with patellar tendinopathy who underwent BM-MSC and Lp-PRP. Bilateral ultrasound tissue characterization scans of the patellar tendon were carried out after 3, 6, and 12 months, as well as tests for strength and pain. UTC patellar tendon was analyzed at the insertion, proximal, and mid-tendon. BM-MSC showed a greater capacity to promote further positive changes than Lp-PRP. Lp-PRP presented higher disorganized echo-type II in the mid-tendon (p = 0.04; ES = 1.06) and III (p = 0.02; ES = −1.47) after 3 months in the Lp-PRP group. Similar results were seen after 6 and 12 months. Pain and strength data show improvement in the treated tendon. BM-MSC treatment demonstrates a superior capacity to promote tendon regeneration and organization, restore strength, and reduce pain compared to Lp-PRP, after 3, 6, and 12 months in male patients with patellar tendinopathy.
Keywords: patellar tendon; imaging; tendinopathy patellar tendon; imaging; tendinopathy

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MDPI and ACS Style

Ortega-Cebrián, S.; Soler-Rich, R.; Orozco, L.; Rodas, G. Evaluation of Patellar Tendon Structural Changes following Biological Treatments: Secondary Analysis of Double-Blinded Clinical Trial of Bone Marrow Mesenchymal Stromal Cells and Leukocyte-Poor Platelet-Rich Plasma. Biomedicines 2024, 12, 1599. https://doi.org/10.3390/biomedicines12071599

AMA Style

Ortega-Cebrián S, Soler-Rich R, Orozco L, Rodas G. Evaluation of Patellar Tendon Structural Changes following Biological Treatments: Secondary Analysis of Double-Blinded Clinical Trial of Bone Marrow Mesenchymal Stromal Cells and Leukocyte-Poor Platelet-Rich Plasma. Biomedicines. 2024; 12(7):1599. https://doi.org/10.3390/biomedicines12071599

Chicago/Turabian Style

Ortega-Cebrián, Silvia, Robert Soler-Rich, Lluis Orozco, and Gil Rodas. 2024. "Evaluation of Patellar Tendon Structural Changes following Biological Treatments: Secondary Analysis of Double-Blinded Clinical Trial of Bone Marrow Mesenchymal Stromal Cells and Leukocyte-Poor Platelet-Rich Plasma" Biomedicines 12, no. 7: 1599. https://doi.org/10.3390/biomedicines12071599

APA Style

Ortega-Cebrián, S., Soler-Rich, R., Orozco, L., & Rodas, G. (2024). Evaluation of Patellar Tendon Structural Changes following Biological Treatments: Secondary Analysis of Double-Blinded Clinical Trial of Bone Marrow Mesenchymal Stromal Cells and Leukocyte-Poor Platelet-Rich Plasma. Biomedicines, 12(7), 1599. https://doi.org/10.3390/biomedicines12071599

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