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Article

Biomarkers and Biochemical Indicators to Evaluate Bone Metabolism in Preterm Neonates

by
Gabriele D’Amato
1,†,
Vincenzo Brescia
2,*,†,
Antonietta Fontana
2,
Maria Pia Natale
1,
Roberto Lovero
2,
Lucia Varraso
2,
Francesca Di Serio
2,
Simonetta Simonetti
3,
Paola Muggeo
4 and
Maria Felicia Faienza
5
1
Neonatal Intensive Care Unit, Di Venere Hospital, 70012 Bari, Italy
2
Clinical Pathology Unit, AOU Policlinico Consorziale di Bari-Ospedale Giovanni XXIII, 70124 Bari, Italy
3
Clinical Pathology and Neonatal Screening, AOU Policlinico Consorziale di Bari-Ospedale Giovanni XXIII, 70124 Bari, Italy
4
Department of Pediatric Oncology and Hematology, AOU Policlinico Consorziale di Bari-Ospedale Giovanni XXIII, 70124 Bari, Italy
5
Pediatric Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari “A. Moro”, 70124 Bari, Italy
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Biomedicines 2024, 12(6), 1271; https://doi.org/10.3390/biomedicines12061271
Submission received: 17 May 2024 / Revised: 3 June 2024 / Accepted: 5 June 2024 / Published: 7 June 2024
(This article belongs to the Special Issue Osteoclast and Osteoblast: Current Status and Future Prospects)
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Abstract

The purpose of the present study was to evaluate the concentrations of some bone turnover markers in preterm neonates with uncomplicated clinical course in the first month of life. Samples from 13 preterm neonates were collected at three different times: at birth (T0) from umbilical cord blood (UCB); and at 15 (T1) and 30 (T2) days of life from peripheral blood (PB). The concentrations of calcium (Ca), phosphate (P), total alkaline phosphatase (ALP), Collagen Type 1 Amino-terminal Propeptide (PINP), osteocalcin (OC), Collagen Type 1 Carboxyl-Terminal Telopeptide (CTX) and Leptin were assessed. A statistically significant difference for ALP concentration at birth versus T1 and T2 was found. An evident increase in the median concentrations of CTX, OC and PINP from T0 to T2 were observed. A significant difference was also found for Leptin concentration at T0 compared to T1. In preterm infants, in the absence of acute or chronic medical conditions and without risk factors for metabolic bone disease (MBD) of prematurity, there is a significant increase in bone turnover markers during the first month of life. The knowledge of the variations in these markers in the first weeks of life, integrated by the variations in the biochemical indicators of bone metabolism, could help in recognizing any conditions at risk of developing bone diseases.
Keywords: preterm newborns; bone biomarkers; total alkaline phosphatase (ALP); collagen type I amino-terminal propeptide (PINP); osteocalcin; collagen type 1 carboxyl-terminal telopeptide (CTX); leptin; metabolic bone disease (MBD) of prematurity preterm newborns; bone biomarkers; total alkaline phosphatase (ALP); collagen type I amino-terminal propeptide (PINP); osteocalcin; collagen type 1 carboxyl-terminal telopeptide (CTX); leptin; metabolic bone disease (MBD) of prematurity

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MDPI and ACS Style

D’Amato, G.; Brescia, V.; Fontana, A.; Natale, M.P.; Lovero, R.; Varraso, L.; Di Serio, F.; Simonetti, S.; Muggeo, P.; Faienza, M.F. Biomarkers and Biochemical Indicators to Evaluate Bone Metabolism in Preterm Neonates. Biomedicines 2024, 12, 1271. https://doi.org/10.3390/biomedicines12061271

AMA Style

D’Amato G, Brescia V, Fontana A, Natale MP, Lovero R, Varraso L, Di Serio F, Simonetti S, Muggeo P, Faienza MF. Biomarkers and Biochemical Indicators to Evaluate Bone Metabolism in Preterm Neonates. Biomedicines. 2024; 12(6):1271. https://doi.org/10.3390/biomedicines12061271

Chicago/Turabian Style

D’Amato, Gabriele, Vincenzo Brescia, Antonietta Fontana, Maria Pia Natale, Roberto Lovero, Lucia Varraso, Francesca Di Serio, Simonetta Simonetti, Paola Muggeo, and Maria Felicia Faienza. 2024. "Biomarkers and Biochemical Indicators to Evaluate Bone Metabolism in Preterm Neonates" Biomedicines 12, no. 6: 1271. https://doi.org/10.3390/biomedicines12061271

APA Style

D’Amato, G., Brescia, V., Fontana, A., Natale, M. P., Lovero, R., Varraso, L., Di Serio, F., Simonetti, S., Muggeo, P., & Faienza, M. F. (2024). Biomarkers and Biochemical Indicators to Evaluate Bone Metabolism in Preterm Neonates. Biomedicines, 12(6), 1271. https://doi.org/10.3390/biomedicines12061271

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