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Volume 12
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Article

Electroretinographical Analysis of the Effect of BGP-15 in Eyedrops for Compensating Global Ischemia–Reperfusion in the Eyes of Sprague Dawley Rats

by
Barbara Takács
1,
Anna Szilágyi
1,
Dániel Priksz
1,
Mariann Bombicz
1,
Adrienn Mónika Szabó
1,
Beáta Pelles-Taskó
1,
Ágnes Rusznyák
2,
Ádám Haimhoffer
3,
Rudolf Gesztelyi
1,
Zoltán Szilvássy
1,
Béla Juhász
1 and
Balázs Varga
1,*
1
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Nagyerdei St. 98, H-4032 Debrecen, Hungary
2
Department of Molecular and Nanopharmaceutics, Faculty of Pharmacy, University of Debrecen, Nagyerdei St. 98, H-4032 Debrecen, Hungary
3
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei St. 98, H-4032 Debrecen, Hungary
*
Author to whom correspondence should be addressed.
Biomedicines 2024, 12(3), 637; https://doi.org/10.3390/biomedicines12030637
Submission received: 11 January 2024 / Revised: 5 March 2024 / Accepted: 10 March 2024 / Published: 13 March 2024
(This article belongs to the Special Issue Molecular Mechanisms and Novel Therapeutic Approaches for Eye Diseases)
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Abstract

Retinal vascular diseases and consequential metabolic disturbances in the eye are major concerns for healthcare systems all around the world. BGP-15, a drug candidate small-molecule [O-(3-piperidino-2-hydroxy-1-propyl) nicotinic amidoxime dihydrochloride], has been formerly demonstrated by our workgroup to be retinoprotective both in the short and long term. Based on these results, the present study was performed to investigate the efficacy of BGP in an eyedrop formulation containing sulfobutylether-β-cyclodextrin (SBECD), which is a solubility enhancer as well. Electroretinographical evaluations were carried out and BGP was demonstrated to improve both scotopic and photopic retinal a- and b-waves, shorten their implicit times and restore oscillatory potentials after ischemia–reperfusion. It was also observed to counteract retinal thinning after ischemia–reperfusion in the eyes of Sprague Dawley rats. This small-molecule drug candidate is able to compensate for experimental global eye ischemia–reperfusion injury elicited by ligation of blood vessels in rats. We successfully demonstrated that BGP is able to exert its protective effects on the retina even if administered in the form of eyedrops.
Keywords: BGP-15; retina; ischemia–reperfusion; electroretinography (ERG); eyedrops; sulfobutylether-β-cyclodextrin (SBECD); ligation BGP-15; retina; ischemia–reperfusion; electroretinography (ERG); eyedrops; sulfobutylether-β-cyclodextrin (SBECD); ligation

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MDPI and ACS Style

Takács, B.; Szilágyi, A.; Priksz, D.; Bombicz, M.; Szabó, A.M.; Pelles-Taskó, B.; Rusznyák, Á.; Haimhoffer, Á.; Gesztelyi, R.; Szilvássy, Z.; et al. Electroretinographical Analysis of the Effect of BGP-15 in Eyedrops for Compensating Global Ischemia–Reperfusion in the Eyes of Sprague Dawley Rats. Biomedicines 2024, 12, 637. https://doi.org/10.3390/biomedicines12030637

AMA Style

Takács B, Szilágyi A, Priksz D, Bombicz M, Szabó AM, Pelles-Taskó B, Rusznyák Á, Haimhoffer Á, Gesztelyi R, Szilvássy Z, et al. Electroretinographical Analysis of the Effect of BGP-15 in Eyedrops for Compensating Global Ischemia–Reperfusion in the Eyes of Sprague Dawley Rats. Biomedicines. 2024; 12(3):637. https://doi.org/10.3390/biomedicines12030637

Chicago/Turabian Style

Takács, Barbara, Anna Szilágyi, Dániel Priksz, Mariann Bombicz, Adrienn Mónika Szabó, Beáta Pelles-Taskó, Ágnes Rusznyák, Ádám Haimhoffer, Rudolf Gesztelyi, Zoltán Szilvássy, and et al. 2024. "Electroretinographical Analysis of the Effect of BGP-15 in Eyedrops for Compensating Global Ischemia–Reperfusion in the Eyes of Sprague Dawley Rats" Biomedicines 12, no. 3: 637. https://doi.org/10.3390/biomedicines12030637

APA Style

Takács, B., Szilágyi, A., Priksz, D., Bombicz, M., Szabó, A. M., Pelles-Taskó, B., Rusznyák, Á., Haimhoffer, Á., Gesztelyi, R., Szilvássy, Z., Juhász, B., & Varga, B. (2024). Electroretinographical Analysis of the Effect of BGP-15 in Eyedrops for Compensating Global Ischemia–Reperfusion in the Eyes of Sprague Dawley Rats. Biomedicines, 12(3), 637. https://doi.org/10.3390/biomedicines12030637

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