Next Article in Journal
Acute Kidney Injury in Hospitalized Patients with COVID-19: Risk Factors and Serum Biomarkers
Previous Article in Journal
A Pig Model to Assess Skin Lesions after Apomorphine Application
Previous Article in Special Issue
Hormonal and Genetic Regulatory Events in Breast Cancer and Its Therapeutics: Importance of the Steroidogenic Acute Regulatory Protein
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Biomedicines
Volume 11
Issue 5
10.3390/biomedicines11051245
biomedicines-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Metallic Nanoparticles: Their Potential Role in Breast Cancer Immunotherapy via Trained Immunity Provocation

by
Elham Zarenezhad
1,
Manal Hadi Ghaffoori Kanaan
2,
Sura Saad Abdollah
3,
Mohammad Kazem Vakil
1,
Mahrokh Marzi
1,*,
Abdulbaset Mazarzaei
4 and
Abdolmajid Ghasemian
1,*
1
Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa 7461686688, Iran
2
Department of Agriculture, Technical Institute of Suwaria, Middle Technical University, Baghdad 9768876516, Iraq
3
Suwaria Primary Health Care Sector, Wassit Health Office, Sharjah 9668866516, Iraq
4
Department of Immunology, School of Medicine, Iranshahr University of Medical Sciences, Iranshahr 7618815676, Iran
*
Authors to whom correspondence should be addressed.
Biomedicines 2023, 11(5), 1245; https://doi.org/10.3390/biomedicines11051245
Submission received: 19 September 2022 / Revised: 19 October 2022 / Accepted: 4 November 2022 / Published: 23 April 2023
(This article belongs to the Special Issue Breast Cancer: Molecular Basis and Translational Research)
Browse Figures
Review Reports Versions Notes

Abstract

Owing to drawbacks in the current common cancer therapies including surgery, chemotherapy and radiotherapy, the development of more reliable, low toxic, cost-effective and specific approaches such as immunotherapy is crucial. Breast cancer is among the leading causes of morbidity and mortality with a developed anticancer resistance. Accordingly, we attempted to uncover the efficacy of metallic nanoparticles (MNPs)-based breast cancer immunotherapy emphasizing trained immunity provocation or innate immunity adaptation. Due to the immunosuppressive nature of the tumor microenvironment (TME) and the poor infiltration of immune cells, the potentiation of an immune response or direct combat is a goal employing NPs as a burgeoning field. During the recent decades, the adaptation of the innate immunity responses against infectious diseases and cancer has been recognized. Although the data is in a scarcity with regard to a trained immunity function in breast cancer cells’ elimination, this study introduced the potential of this arm of immunity adaptation using MNPs.
Keywords: breast cancer; nanoparticles; trained immunity; cancer therapy; drug delivery breast cancer; nanoparticles; trained immunity; cancer therapy; drug delivery

Share and Cite

MDPI and ACS Style

Zarenezhad, E.; Kanaan, M.H.G.; Abdollah, S.S.; Vakil, M.K.; Marzi, M.; Mazarzaei, A.; Ghasemian, A. Metallic Nanoparticles: Their Potential Role in Breast Cancer Immunotherapy via Trained Immunity Provocation. Biomedicines 2023, 11, 1245. https://doi.org/10.3390/biomedicines11051245

AMA Style

Zarenezhad E, Kanaan MHG, Abdollah SS, Vakil MK, Marzi M, Mazarzaei A, Ghasemian A. Metallic Nanoparticles: Their Potential Role in Breast Cancer Immunotherapy via Trained Immunity Provocation. Biomedicines. 2023; 11(5):1245. https://doi.org/10.3390/biomedicines11051245

Chicago/Turabian Style

Zarenezhad, Elham, Manal Hadi Ghaffoori Kanaan, Sura Saad Abdollah, Mohammad Kazem Vakil, Mahrokh Marzi, Abdulbaset Mazarzaei, and Abdolmajid Ghasemian. 2023. "Metallic Nanoparticles: Their Potential Role in Breast Cancer Immunotherapy via Trained Immunity Provocation" Biomedicines 11, no. 5: 1245. https://doi.org/10.3390/biomedicines11051245

APA Style

Zarenezhad, E., Kanaan, M. H. G., Abdollah, S. S., Vakil, M. K., Marzi, M., Mazarzaei, A., & Ghasemian, A. (2023). Metallic Nanoparticles: Their Potential Role in Breast Cancer Immunotherapy via Trained Immunity Provocation. Biomedicines, 11(5), 1245. https://doi.org/10.3390/biomedicines11051245

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop