Next Article in Journal
Intelligent Bi-LSTM with Architecture Optimization for Heart Disease Prediction in WBAN through Optimal Channel Selection and Feature Selection
Next Article in Special Issue
Intramuscular Polydeoxyribonucleotides in Fibrotic and Atrophic Localized Scleroderma: An Explorative Prospective Cohort Study
Previous Article in Journal
The Emergence of TRP Channels Interactome as a Potential Therapeutic Target in Pancreatic Ductal Adenocarcinoma
Previous Article in Special Issue
Rapamycin Treatment Alleviates Chronic GVHD-Induced Lupus Nephritis in Mice by Recovering IL-2 Production and Regulatory T Cells While Inhibiting Effector T Cells Activation
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Biomedicines
Volume 11
Issue 4
10.3390/biomedicines11041165
Review Report
biomedicines-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Review
Peer-Review Record

Lupus Nephritis and Dysbiosis

Biomedicines 2023, 11(4), 1165; https://doi.org/10.3390/biomedicines11041165
by Marta Monticolo 1, Krzysztof Mucha 1,2 and Bartosz Foroncewicz 1,*
Reviewer 1:
Qingjun Pan
Reviewer 2:
Tsvetelina Velikova
Biomedicines 2023, 11(4), 1165; https://doi.org/10.3390/biomedicines11041165
Submission received: 26 February 2023 / Revised: 29 March 2023 / Accepted: 31 March 2023 / Published: 13 April 2023
(This article belongs to the Special Issue Autoimmune Diseases: Mechanisms and Novel Therapeutic Approaches)

Round 1

Reviewer 1 Report

This topic has been well reviewed recently which can be searched with Pubmed, and very few orinial studies were reported, and no novel fings recently.

Also, as the author stated, the risk factors for developing LN by SLE patients are not fully understood, especially for the role of dysbiosis in LN. 

So, in my opinion, the part of conclusions need to be reconsidered, for examlple: "Obviously, dysbiosis itself is not responsible for disease development.", "The next step in linking dysbiosis to LN would be identification of microbial peptides that mimick antigens that initiate autoantibodies production."

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

The article is consistent within itself. The references are relevant and recent. The cited sources are referenced correctly. Appropriate and key studies are included. The paper is comprehensive, the flow is logical and the data is presented critically.

However, there are some specific comments on weaknesses of the article and what could be improved:

Major points - none

 

Minor points

1. What is the search strategy for this review - which databases did you use, which keywords and combination.

2. What is still a challenge - please, add at the end.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Round 2

Reviewer 1 Report

For your response to reviewers, "In our research, we mainly used combinations of the words "lupus nephritis" and "dysbiosis"; "dysbiosis" and "genetic predisposition"; "microbiome" and "lupus nephritis."

In addition to "lupus nephritis", "Systemic Lupus Erythematosus" is also suggested to added to the key words, these two words cannot be seperately clearly. Then, you will find other close related references for this topic, e.g. Gut Microbiota Dysbiosis in Systemic Lupus Erythematosus: Novel Insights into Mechanisms and Promising Therapeutic Strategies. Front Immunol. 2021 Dec 3;12:799788.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Back to TopTop