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Biomedicines
Volume 11
Issue 4
10.3390/biomedicines11041074
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Article

Light Alcohol Consumption Promotes Early Neurogenesis Following Ischemic Stroke in Adult C57BL/6J Mice

by
Jiyu Li
1,
Chun Li
1,
Pushpa Subedi
1,
Xinli Tian
2,
Xiaohong Lu
2,
Sumitra Miriyala
1,
Manikandan Panchatcharam
1 and
Hong Sun
1,*
1
Department of Cellular Biology & Anatomy, LSUHSC-Shreveport, Shreveport, LA 71103, USA
2
Department of Pharmacology, Toxicology & Neuroscience, LSUHSC-Shreveport, Shreveport, LA 71103, USA
*
Author to whom correspondence should be addressed.
Biomedicines 2023, 11(4), 1074; https://doi.org/10.3390/biomedicines11041074
Submission received: 27 February 2023 / Revised: 20 March 2023 / Accepted: 31 March 2023 / Published: 2 April 2023
(This article belongs to the Special Issue 10th Anniversary of Biomedicines—Translational Laboratory and Experimental Medicine for the Sake of Neurological Diseases and Mental Illnesses)
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Abstract

Ischemic stroke is one of the leading causes of death and disability worldwide. Neurogenesis plays a crucial role in postischemic functional recovery. Alcohol dose-dependently affects the prognosis of ischemic stroke. We investigated the impact of light alcohol consumption (LAC) on neurogenesis under physiological conditions and following ischemic stroke. C57BL/6J mice (three months old) were fed with 0.7 g/kg/day ethanol (designed as LAC) or volume-matched water (designed as control) daily for eight weeks. To evaluate neurogenesis, the numbers of 5-bromo-2-deoxyuridine (BrdU)+/doublecortin (DCX)+ and BrdU+/NeuN+ neurons were assessed in the subventricular zone (SVZ), dentate gyrus (DG), ischemic cortex, and ischemic striatum. The locomotor activity was determined by the accelerating rotarod and open field tests. LAC significantly increased BrdU+/DCX+ and BrdU+/NeuN+ cells in the SVZ under physiological conditions. Ischemic stroke dramatically increased BrdU+/DCX+ and BrdU+/NeuN+ cells in the DG, SVZ, ischemic cortex, and ischemic striatum. The increase in BrdU+/DCX+ cells was significantly greater in LAC mice compared to the control mice. In addition, LAC significantly increased BrdU+/NeuN+ cells by about three folds in the DG, SVZ, and ischemic cortex. Furthermore, LAC reduced ischemic brain damage and improved locomotor activity. Therefore, LAC may protect the brain against ischemic stroke by promoting neurogenesis.
Keywords: alcohol; brain; neurogenesis; subventricular zone; dentate gyrus; ischemia; reperfusion; rotarod test; open field test; mice alcohol; brain; neurogenesis; subventricular zone; dentate gyrus; ischemia; reperfusion; rotarod test; open field test; mice

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MDPI and ACS Style

Li, J.; Li, C.; Subedi, P.; Tian, X.; Lu, X.; Miriyala, S.; Panchatcharam, M.; Sun, H. Light Alcohol Consumption Promotes Early Neurogenesis Following Ischemic Stroke in Adult C57BL/6J Mice. Biomedicines 2023, 11, 1074. https://doi.org/10.3390/biomedicines11041074

AMA Style

Li J, Li C, Subedi P, Tian X, Lu X, Miriyala S, Panchatcharam M, Sun H. Light Alcohol Consumption Promotes Early Neurogenesis Following Ischemic Stroke in Adult C57BL/6J Mice. Biomedicines. 2023; 11(4):1074. https://doi.org/10.3390/biomedicines11041074

Chicago/Turabian Style

Li, Jiyu, Chun Li, Pushpa Subedi, Xinli Tian, Xiaohong Lu, Sumitra Miriyala, Manikandan Panchatcharam, and Hong Sun. 2023. "Light Alcohol Consumption Promotes Early Neurogenesis Following Ischemic Stroke in Adult C57BL/6J Mice" Biomedicines 11, no. 4: 1074. https://doi.org/10.3390/biomedicines11041074

APA Style

Li, J., Li, C., Subedi, P., Tian, X., Lu, X., Miriyala, S., Panchatcharam, M., & Sun, H. (2023). Light Alcohol Consumption Promotes Early Neurogenesis Following Ischemic Stroke in Adult C57BL/6J Mice. Biomedicines, 11(4), 1074. https://doi.org/10.3390/biomedicines11041074

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