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Article

The Prognosis Performance of a Neutrophil- and Lymphocyte-Associated Gene Mutation Score in a Head and Neck Cancer Cohort

by
Tsung-Jang Yeh
1,2,3,
Hui-Ching Wang
1,2,4,
Shih-Feng Cho
1,3,4,
Chun-Chieh Wu
5,
Tzu-Yu Hsieh
1,
Chien-Tzu Huang
1,2,
Min-Hong Wang
1,2,
Tzer-Ming Chuang
1,
Yuh-Ching Gau
1,2,
Jeng-Shiun Du
1,2,
Yi-Chang Liu
1,3,4,
Hui-Hua Hsiao
1,3,4,
Mei-Ren Pan
2,6,7,
Li-Tzong Chen
3,8,9 and
Sin-Hua Moi
2,10,*
1
Division of Hematology & Oncology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan
2
Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
3
Center for Cancer Research, Kaohsiung Medical University, Kaohsiung 807, Taiwan
4
Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
5
Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan
6
Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung 807, Taiwan
7
Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan
8
Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan
9
National Institute of Cancer Research, National Health Research Institutes, Tainan 704, Taiwan
10
Research Center for Precision Environmental Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
*
Author to whom correspondence should be addressed.
Biomedicines 2023, 11(12), 3113; https://doi.org/10.3390/biomedicines11123113
Submission received: 8 May 2023 / Revised: 16 November 2023 / Accepted: 21 November 2023 / Published: 22 November 2023
(This article belongs to the Special Issue Oral Cancer: From Pathophysiology to Novel Therapeutic Approaches)
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Abstract

The treatment of head and neck squamous cell carcinomas (HNSCCs) is multimodal, and chemoradiotherapy (CRT) is a critical component. However, the availability of predictive or prognostic markers in patients with HNSCC is limited. Inflammation is a well-documented factor in cancer, and several parameters have been studied, with the neutrophil-to-lymphocyte ratio (NLR) being the most promising. The NLR is the most extensively researched clinical biomarker in various solid tumors, including HNSCC. In our study, we collected clinical and next-generation sequencing (NGS) data with targeted sequencing information from 107 patients with HNSCC who underwent CRT. The difference in the NLR between the good response group and the poor response group was significant, with more patients having a high NLR in the poor response group. We also examined the genetic alterations linked to the NLR and found a total of 41 associated genes across eight common pathways searched from the KEGG database. The overall mutation rate was low, and there was no significant mutation difference between the low- and high-NLR groups. Using a multivariate binomial generalized linear model, we identified three candidate genes (MAP2K2, MAP2K4, and ABL1) that showed significant results and were used to create a gene mutation score (GMS). Using the NLR-GMS category, we noticed that the high-NLR-GMS group had significantly shorter relapse-free survival compared to the intermediate- or low-NLR-GMS groups.
Keywords: genomic mutation signature; neutrophil to lymphocyte ratio; head and neck cancer; prognostic biomarker genomic mutation signature; neutrophil to lymphocyte ratio; head and neck cancer; prognostic biomarker
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MDPI and ACS Style

Yeh, T.-J.; Wang, H.-C.; Cho, S.-F.; Wu, C.-C.; Hsieh, T.-Y.; Huang, C.-T.; Wang, M.-H.; Chuang, T.-M.; Gau, Y.-C.; Du, J.-S.; et al. The Prognosis Performance of a Neutrophil- and Lymphocyte-Associated Gene Mutation Score in a Head and Neck Cancer Cohort. Biomedicines 2023, 11, 3113. https://doi.org/10.3390/biomedicines11123113

AMA Style

Yeh T-J, Wang H-C, Cho S-F, Wu C-C, Hsieh T-Y, Huang C-T, Wang M-H, Chuang T-M, Gau Y-C, Du J-S, et al. The Prognosis Performance of a Neutrophil- and Lymphocyte-Associated Gene Mutation Score in a Head and Neck Cancer Cohort. Biomedicines. 2023; 11(12):3113. https://doi.org/10.3390/biomedicines11123113

Chicago/Turabian Style

Yeh, Tsung-Jang, Hui-Ching Wang, Shih-Feng Cho, Chun-Chieh Wu, Tzu-Yu Hsieh, Chien-Tzu Huang, Min-Hong Wang, Tzer-Ming Chuang, Yuh-Ching Gau, Jeng-Shiun Du, and et al. 2023. "The Prognosis Performance of a Neutrophil- and Lymphocyte-Associated Gene Mutation Score in a Head and Neck Cancer Cohort" Biomedicines 11, no. 12: 3113. https://doi.org/10.3390/biomedicines11123113

APA Style

Yeh, T.-J., Wang, H.-C., Cho, S.-F., Wu, C.-C., Hsieh, T.-Y., Huang, C.-T., Wang, M.-H., Chuang, T.-M., Gau, Y.-C., Du, J.-S., Liu, Y.-C., Hsiao, H.-H., Pan, M.-R., Chen, L.-T., & Moi, S.-H. (2023). The Prognosis Performance of a Neutrophil- and Lymphocyte-Associated Gene Mutation Score in a Head and Neck Cancer Cohort. Biomedicines, 11(12), 3113. https://doi.org/10.3390/biomedicines11123113

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