Development of a Multifunctional Oral Dosage Form via Integration of Solid Dispersion Technology with a Black Seed Oil-Based Self-Nanoemulsifying Drug Delivery System
Abstract
:1. Introduction
2. Materials and Methods
2.1. Procurement of Plant Material and Isolation of Bioactive Components
2.2. Chemical and Reagents
2.3. Preparation and Characterization of LZP-SNEDDS
2.4. Preparation of Solid Dispersion (SD) Formulation
2.4.1. Microwave Method
2.4.2. Lyophilization Method
2.5. Scanning Electron Microscopy (SEM)
2.6. Differential Scanning Calorimetry (DSC)
2.7. Powder X-ray Powder Diffraction (PXRD)
2.8. In Vitro Dissolution Test
2.9. Stability Study
2.10. Quantification of LZP Using the Developed UPLC-UV Method
2.11. Software
2.12. Statistical Analysis
3. Results
3.1. Characterization of Lansoprazole-Loaded Self-Nanoemulsifying Delivery System
3.2. SEM
3.2.1. Microwave Method
3.2.2. Lyophilization Method
3.3. DSC
3.3.1. Microwave Method
3.3.2. Lyophilization Method
3.4. PXRD
3.5. In Vitro Dissolution Studies
3.5.1. SNEDDS Formulations
3.5.2. SD Formulation
3.5.3. SD Formulation + Drug-Free Bioactive SNEDDS
3.6. Stability Study
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Formulation Code | LZP | PF-127 | PEG-4000 | HPMC | Sodium Hydrogen Carbonate (NaHCO3) | Disodium Carbonate (Na2CO3) |
---|---|---|---|---|---|---|
MW-PF-127 | 1.0 | 4.0 | - | - | - | - |
MW-PEG 4000 | 1.0 | - | 4.0 | - | - | - |
LP-PF-127 | 1.0 | 4.0 | - | - | 1.4 | 12.6 |
LP-HPMC | 1.0 | - | - | 4.0 | 1.4 | 12.6 |
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Sherif, A.Y.; Shahba, A.A.-W. Development of a Multifunctional Oral Dosage Form via Integration of Solid Dispersion Technology with a Black Seed Oil-Based Self-Nanoemulsifying Drug Delivery System. Biomedicines 2023, 11, 2733. https://doi.org/10.3390/biomedicines11102733
Sherif AY, Shahba AA-W. Development of a Multifunctional Oral Dosage Form via Integration of Solid Dispersion Technology with a Black Seed Oil-Based Self-Nanoemulsifying Drug Delivery System. Biomedicines. 2023; 11(10):2733. https://doi.org/10.3390/biomedicines11102733
Chicago/Turabian StyleSherif, Abdelrahman Y., and Ahmad Abdul-Wahhab Shahba. 2023. "Development of a Multifunctional Oral Dosage Form via Integration of Solid Dispersion Technology with a Black Seed Oil-Based Self-Nanoemulsifying Drug Delivery System" Biomedicines 11, no. 10: 2733. https://doi.org/10.3390/biomedicines11102733