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Volume 11
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10.3390/biomedicines11010190
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Review
Peer-Review Record

Wnt/β-Catenin Signaling and Resistance to Immune Checkpoint Inhibitors: From Non-Small-Cell Lung Cancer to Other Cancers

Biomedicines 2023, 11(1), 190; https://doi.org/10.3390/biomedicines11010190
by Satoshi Muto *, Akio Enta, Yoshiyuki Maruya, Sho Inomata, Hikaru Yamaguchi, Hayato Mine, Hironori Takagi, Yuki Ozaki, Masayuki Watanabe, Takuya Inoue, Takumi Yamaura, Mitsuro Fukuhara, Naoyuki Okabe, Yuki Matsumura, Takeo Hasegawa, Jun Osugi, Mika Hoshino, Mitsunori Higuchi, Yutaka Shio, Kazuyuki Hamada and Hiroyuki Suzukiadd Show full author list remove Hide full author list
Reviewer 1:
Izabela Chmielewska
Reviewer 2:
Yi Huang
Reviewer 3: Anonymous
Biomedicines 2023, 11(1), 190; https://doi.org/10.3390/biomedicines11010190
Submission received: 22 December 2022 / Accepted: 6 January 2023 / Published: 12 January 2023
(This article belongs to the Special Issue 10th Anniversary of Biomedicines: The Development of Cancer Immunotherapy)

Round 1

Reviewer 1 Report

This article provides an overview of the current understanding of the mechanisms of resistance to immune checkpoint inhibitors in NSCLC and other cancers. It highlights the important role of the Wnt/β-catenin pathway in tumor escape and immunomodulation, and identifies potential therapeutic strategies targeting this pathway. The authors' conclusions are supported by a comprehensive review of the relevant literature. This review is an important contribution to our understanding of the mechanisms of immune checkpoint inhibitor resistance in NSCLC and other cancers, and is a valuable resource for researchers and clinicians.

Reviewer 2 Report

Overall, this is a very well-written manuscript. The author showed a detailed introduction; the Wnt/β-catenin pathway is clearly depicted and easy to understand. The checkpoint inhibitor resistance with Wnt/β-catenin signaling is well presented and easy to follow. The conclusion part is also well presented. I don't see any concerns in this article.  

Reviewer 3 Report

Title: Wnt/β-catenin Signaling and Resistance to Immune Check-point Inhibitors: From Non-Small Cell Lung Cancer to Other Cancers

ID: biomedicines-2146132

Article Type: Review

Journal: Biomedicines

Section: Immunology and Immunotherapy

The aim of the present review was to summarize findings on mechanisms of resistance to immune checkpoint inhibitors in Non-Small Cell Lung Cancer (NSCLC) and other cancers, focusing on Wnt/β-catenin signaling. In particular, the authors reviewed the molecular biology of Wnt/β-catenin signaling, and then discussed how it can induce immunoediting and resistance to immune checkpoint inhibitors. In addition, the authors described other mechanisms of immune checkpoint inhibitor resistance. Finally, they proposed therapeutic approaches to overcome these mechanisms.

The work is exhaustive and it is written very well, the concepts are clearly explained. For me there are no relevant changes to make.

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