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Biomedicines
Volume 10
Issue 7
10.3390/biomedicines10071600
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Review

Role of Interleukins and New Perspectives in Mechanisms of Resistance to Chemotherapy in Gastric Cancer

by
Marlena Janiczek-Polewska
1,2,*,
Łukasz Szylberg
3,4,
Julian Malicki
1,† and
Andrzej Marszałek
5,†
1
Department of Electroradiology, Poznan University of Medical Sciences, 61-701 Poznan, Poland
2
Department of Clinical Oncology, Greater Poland Cancer Center, 61-866 Poznan, Poland
3
Department of Perinatology, Gynaecology and Gynaecologic Oncology, Collegium Medicum, Nicolaus Copernicus University, 85-067 Bydgoszcz, Poland
4
Department of Tumor Pathology and Pathomorphology, Oncology Centrer of Franciszek Łukaszczyk Memorial Hospital, 85-796 Bydgoszcz, Poland
5
Department of Oncologic Pathology, Prophylaxis Poznan University, Medical Sciences and Greater Poland Cancer Center, 61-866 Poznan, Poland
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Biomedicines 2022, 10(7), 1600; https://doi.org/10.3390/biomedicines10071600
Submission received: 8 June 2022 / Revised: 26 June 2022 / Accepted: 30 June 2022 / Published: 5 July 2022
(This article belongs to the Special Issue The Role of Inflammatory Cytokines in Cancer Progression)
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Abstract

Gastric cancer (GC) is the fourth most common cancer in the world in terms of incidence and second in terms of mortality. Chemotherapy is the main treatment for GC. The greatest challenge and major cause of GC treatment failure is resistance to chemotherapy. As such, research is ongoing into molecular evaluation, investigating mechanisms, and screening therapeutic targets. Several mechanisms related to both the tumor cells and the tumor microenvironment (TME) are involved in resistance to chemotherapy. TME promotes the secretion of various inflammatory cytokines. Recent studies have revealed that inflammatory cytokines affect not only tumor growth, but also chemoresistance. Cytokines in TME can be detected in blood circulation and TME cells. Inflammatory cytokines could serve as potential biomarkers in the assessment of chemoresistance and influence the management of therapeutics in GC. This review presents recent data concerning research on inflammatory cytokines involved in the mechanisms of chemoresistance and provides new clues in GC treatment.
Keywords: gastric cancer; interleukins; cytokines; chemoresistance; tumor microenvironment gastric cancer; interleukins; cytokines; chemoresistance; tumor microenvironment

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MDPI and ACS Style

Janiczek-Polewska, M.; Szylberg, Ł.; Malicki, J.; Marszałek, A. Role of Interleukins and New Perspectives in Mechanisms of Resistance to Chemotherapy in Gastric Cancer. Biomedicines 2022, 10, 1600. https://doi.org/10.3390/biomedicines10071600

AMA Style

Janiczek-Polewska M, Szylberg Ł, Malicki J, Marszałek A. Role of Interleukins and New Perspectives in Mechanisms of Resistance to Chemotherapy in Gastric Cancer. Biomedicines. 2022; 10(7):1600. https://doi.org/10.3390/biomedicines10071600

Chicago/Turabian Style

Janiczek-Polewska, Marlena, Łukasz Szylberg, Julian Malicki, and Andrzej Marszałek. 2022. "Role of Interleukins and New Perspectives in Mechanisms of Resistance to Chemotherapy in Gastric Cancer" Biomedicines 10, no. 7: 1600. https://doi.org/10.3390/biomedicines10071600

APA Style

Janiczek-Polewska, M., Szylberg, Ł., Malicki, J., & Marszałek, A. (2022). Role of Interleukins and New Perspectives in Mechanisms of Resistance to Chemotherapy in Gastric Cancer. Biomedicines, 10(7), 1600. https://doi.org/10.3390/biomedicines10071600

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