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The Determinants of Liver Fibrosis in Patients with Nonalcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus

by 1,2, 3, 4, 2,5,6,*,† and 2,7,8,9,10,*,†
1
Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan
2
School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
3
Division of Geriatrics and Gerontology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
4
Division of Endocrinology and Metabolism, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
5
Department of Family Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung 801, Taiwan
6
Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
7
Division of General Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
8
Division of Nephrology, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
9
Liquid Biopsy and Cohort Research Center, Kaohsiung Medical University, Kaohsiung 807, Taiwan
10
Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung 807, Taiwan
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: François R. Jornayvaz and Karim Gariani
Biomedicines 2022, 10(7), 1487; https://doi.org/10.3390/biomedicines10071487
Received: 30 May 2022 / Revised: 19 June 2022 / Accepted: 21 June 2022 / Published: 23 June 2022
Liver fibrosis is a key pathophysiology process in chronic liver disease. It is still unclear whether the impact of liver fibrosis is not fully realized in type 2 diabetes mellitus (T2D) patients with nonalcoholic fatty liver disease (NAFLD), and the factors affecting nonalcoholic steatohepatitis (NASH) or liver stiffness also remain unclear. The aim of this study was to evaluate the determinants of liver fibrosis and in T2D patients with NAFLD. Liver fibrosis and steatosis were measured using transient elastography (FibroScan). Of 226 T2D patients with NAFLD, 50 with liver fibrosis had higher body mass index, serum uric acid, triglyceride and glycated hemoglobin levels and lower high density lipoprotein levels than 176 without liver fibrosis. Multivariate analysis revealed that aging, obesity, sulfonylurea usage and high levels of AST increased the risk of liver fibrosis in T2D patients with NAFLD. Our findings provide useful information to clinical physicians for earlier detection of liver fibrosis in T2D patients with NAFLD and to prevent liver fibrosis through controlling these risk factors. View Full-Text
Keywords: liver fibrosis; type 2 diabetes mellitus; NAFLD; fibroscan liver fibrosis; type 2 diabetes mellitus; NAFLD; fibroscan
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MDPI and ACS Style

Dai, C.-Y.; Fang, T.-J.; Hung, W.-W.; Tsai, H.-J.; Tsai, Y.-C. The Determinants of Liver Fibrosis in Patients with Nonalcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus. Biomedicines 2022, 10, 1487. https://doi.org/10.3390/biomedicines10071487

AMA Style

Dai C-Y, Fang T-J, Hung W-W, Tsai H-J, Tsai Y-C. The Determinants of Liver Fibrosis in Patients with Nonalcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus. Biomedicines. 2022; 10(7):1487. https://doi.org/10.3390/biomedicines10071487

Chicago/Turabian Style

Dai, Chia-Yen, Tzu-Jung Fang, Wei-Wen Hung, Hui-Ju Tsai, and Yi-Chun Tsai. 2022. "The Determinants of Liver Fibrosis in Patients with Nonalcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus" Biomedicines 10, no. 7: 1487. https://doi.org/10.3390/biomedicines10071487

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