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Article

Intraovarian Injection of Recombinant Human Follicle-Stimulating Hormone for Luteal-Phase Ovarian Stimulation during Oocyte Retrieval Is Effective in Women with Impending Ovarian Failure and Diminished Ovarian Reserve

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Taiwan United Birth-Promoting Experts Fertility Clinic, Tainan 710, Taiwan
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Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei 100, Taiwan
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Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, Tainan 701, Taiwan
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Nepean Hospital, Penrith, NSW 2747, Australia
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Department of Medical Science Industries, College of Health Sciences, Chang Jung Christian University, Tainan 711, Taiwan
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Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
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School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
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Department of Pharmacy, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
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Department of Pharmacy, National Cheng Kung University Hospital, Dou-Liou Branch, Yunlin 640, Taiwan
*
Authors to whom correspondence should be addressed.
Academic Editor: Jae Ho Lee
Biomedicines 2022, 10(6), 1312; https://doi.org/10.3390/biomedicines10061312
Received: 15 April 2022 / Revised: 31 May 2022 / Accepted: 1 June 2022 / Published: 3 June 2022
(This article belongs to the Special Issue Molecular and Cellular Biology in Reproductive Medicine)
It is a challenge to obtain sufficient eggs during in vitro fertilization (IVF) in women with impending ovarian failure (IOF)/diminished ovarian reserve (DOR). Although studies have suggested that more than one wave of follicle growth exists, the efficacy of controlled ovulation stimulation (COS) in both follicular and luteal phases of the same ovarian cycle (DuoStim) is not established in women with IOF/DOR. We investigated the efficacy of DuoStim using the intraovarian injection of recombinant human follicle-stimulating hormone (rhFSH) during oocyte retrieval in women with DOR. For luteal-phase stimulation, intraovarian (Group A, N = 28) or superficial subcutaneous (Group B, N = 18) injection of 300 IU rhFSH immediately after oocyte retrieval was administered as the first dose, and intermittent superficial subcutaneous addition of gonadotropins was employed accordingly for further COS in both groups. In Group A, significantly lower Gn doses, a shorter duration of COS, a greater number of antral follicle counts, and an increased number of retrieved mature and total oocytes were noted. Compared with the clinical outcomes of luteal-phase COS, the average daily doses of rhFSH used in Group A were significantly lower. In summary, the novel approach using intraovarian rhFSH injection provides an efficient treatment regimen in women with IOF/DOR. View Full-Text
Keywords: diminished ovarian reserve; impending ovarian failure; intraovarian; luteal phase; recombinant human follicle-stimulating hormone; controlled ovulation stimulation; DuoStim diminished ovarian reserve; impending ovarian failure; intraovarian; luteal phase; recombinant human follicle-stimulating hormone; controlled ovulation stimulation; DuoStim
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MDPI and ACS Style

Hsu, C.-C.; Hsu, I.; Lee, L.-H.; Hsueh, Y.-S.; Lin, C.-Y.; Chang, H.H. Intraovarian Injection of Recombinant Human Follicle-Stimulating Hormone for Luteal-Phase Ovarian Stimulation during Oocyte Retrieval Is Effective in Women with Impending Ovarian Failure and Diminished Ovarian Reserve. Biomedicines 2022, 10, 1312. https://doi.org/10.3390/biomedicines10061312

AMA Style

Hsu C-C, Hsu I, Lee L-H, Hsueh Y-S, Lin C-Y, Chang HH. Intraovarian Injection of Recombinant Human Follicle-Stimulating Hormone for Luteal-Phase Ovarian Stimulation during Oocyte Retrieval Is Effective in Women with Impending Ovarian Failure and Diminished Ovarian Reserve. Biomedicines. 2022; 10(6):1312. https://doi.org/10.3390/biomedicines10061312

Chicago/Turabian Style

Hsu, Chao-Chin, Isabel Hsu, Li-Hsuan Lee, Yuan-Shuo Hsueh, Chih-Ying Lin, and Hui Hua Chang. 2022. "Intraovarian Injection of Recombinant Human Follicle-Stimulating Hormone for Luteal-Phase Ovarian Stimulation during Oocyte Retrieval Is Effective in Women with Impending Ovarian Failure and Diminished Ovarian Reserve" Biomedicines 10, no. 6: 1312. https://doi.org/10.3390/biomedicines10061312

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