C9orf72 Hexanucleotide Repeat Expansion-Related Neuropathology Is Attenuated by Nasal Rifampicin in Mice
Abstract
:1. Introduction
2. Materials and Methods
2.1. Mice
2.2. Behavioral Tests
2.3. Immunohistochemical Analysis
2.4. Rifampicin Treatment
2.5. Gel Shift Assay for G-Quadruplex
2.6. Immunohistochemistry for Phosphorylated PKR
2.7. Statistical Analysis
3. Results
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Hatanaka, Y.; Umeda, T.; Shigemori, K.; Takeuchi, T.; Nagai, Y.; Tomiyama, T. C9orf72 Hexanucleotide Repeat Expansion-Related Neuropathology Is Attenuated by Nasal Rifampicin in Mice. Biomedicines 2022, 10, 1080. https://doi.org/10.3390/biomedicines10051080
Hatanaka Y, Umeda T, Shigemori K, Takeuchi T, Nagai Y, Tomiyama T. C9orf72 Hexanucleotide Repeat Expansion-Related Neuropathology Is Attenuated by Nasal Rifampicin in Mice. Biomedicines. 2022; 10(5):1080. https://doi.org/10.3390/biomedicines10051080
Chicago/Turabian StyleHatanaka, Yukari, Tomohiro Umeda, Keiko Shigemori, Toshihide Takeuchi, Yoshitaka Nagai, and Takami Tomiyama. 2022. "C9orf72 Hexanucleotide Repeat Expansion-Related Neuropathology Is Attenuated by Nasal Rifampicin in Mice" Biomedicines 10, no. 5: 1080. https://doi.org/10.3390/biomedicines10051080
APA StyleHatanaka, Y., Umeda, T., Shigemori, K., Takeuchi, T., Nagai, Y., & Tomiyama, T. (2022). C9orf72 Hexanucleotide Repeat Expansion-Related Neuropathology Is Attenuated by Nasal Rifampicin in Mice. Biomedicines, 10(5), 1080. https://doi.org/10.3390/biomedicines10051080