Growth Factors Do Not Improve Muscle Function in Young or Adult mdx Mice
1
Copenhagen Neuromuscular Center, Department of Neurology, Rigshospitalet, University of Copenhagen, DK-2100 Copenhagen, Denmark
2
Mitochondrial and Neuromuscular Disorders Unit, Vall d’Hebron Institut de Recerca, Universitat Autònoma de Barcelona, 08035 Barcelona, Spain
3
Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), 28029 Madrid, Spain
4
Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, The Panum Institute, University of Copenhagen, DK-2200 Copenhagen, Denmark
*
Author to whom correspondence should be addressed.
Academic Editor: Marco Segatto
Biomedicines 2022, 10(2), 304; https://doi.org/10.3390/biomedicines10020304
Received: 6 January 2022
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Revised: 21 January 2022
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Accepted: 27 January 2022
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Published: 28 January 2022
(This article belongs to the Section Neurobiology and Neurologic Disease)
Muscular dystrophies constitute a broad group of genetic disorders leading to muscle wasting. We have previously demonstrated that treating a muscular atrophy mouse model with growth factors resulted in increased muscle mass. In the present study, we treated the Duchenne mouse model mdx for 12 weeks with myogenic growth factors peri- and post-onset of muscular degeneration to explore the effects in the oxidative muscle soleus and the glycolytic muscle extensor digitorum longus (EDL). We found no overall beneficial effect in the peri-onset group at the conclusion of the study. In the post-onset group, the functional improvement by means of electrophysiological examinations ex vivo was mostly confined to the soleus. EDL benefitted from the treatment on a molecular level but did not improve functionally. Histopathology revealed signs of inflammation at the end of treatment. In conclusion, the growth factor cocktail failed to improve the mdx on a functional level.
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MDPI and ACS Style
Nielsen, T.L.; Hornsyld, T.M.; Pinós, T.; Brolin, C.; Vissing, J.; Krag, T.O. Growth Factors Do Not Improve Muscle Function in Young or Adult mdx Mice. Biomedicines 2022, 10, 304. https://doi.org/10.3390/biomedicines10020304
AMA Style
Nielsen TL, Hornsyld TM, Pinós T, Brolin C, Vissing J, Krag TO. Growth Factors Do Not Improve Muscle Function in Young or Adult mdx Mice. Biomedicines. 2022; 10(2):304. https://doi.org/10.3390/biomedicines10020304
Chicago/Turabian StyleNielsen, Tue L., Tessa M. Hornsyld, Tomàs Pinós, Camilla Brolin, John Vissing, and Thomas O. Krag. 2022. "Growth Factors Do Not Improve Muscle Function in Young or Adult mdx Mice" Biomedicines 10, no. 2: 304. https://doi.org/10.3390/biomedicines10020304
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