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Biomedicines
Volume 10
Issue 11
10.3390/biomedicines10112831
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Article

Adenosine Receptors Profile in Fibromuscular Dysplasia

by
Claire Guiol
1,
Sarah El Harake
2,
Julien Fromonot
1,3,
Mohamed Chefrour
3,
Marguerite Gastaldi
1,3,
Yassine Alibouch
3,
Maxime Doublier
3,
Pierre Deharo
1,4,
Gabrielle Sarlon
2,
Marion Marlinge
1,3,
Nathalie Lalevee
1,
Régis Guieu
1,3,* and
François Silhol
2
1
Centre for Cardiovascular Research and Nutrition, C2VN, INSERM, INRAE, Aix Marseille University, 13000 Marseille, France
2
Hypertension Department, Pôle Cardio-Vasculaire, Timone University Hospital, 13000 Marseille, France
3
Laboratory of Biochemistry, Timone University Hospital, 13000 Marseille, France
4
Department of Cardiology, Timone University Hospital, 13000 Marseille, France
*
Author to whom correspondence should be addressed.
Biomedicines 2022, 10(11), 2831; https://doi.org/10.3390/biomedicines10112831
Submission received: 6 October 2022 / Revised: 19 October 2022 / Accepted: 2 November 2022 / Published: 6 November 2022
(This article belongs to the Special Issue Advances in Adenosine and Adenosine Receptors)
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Abstract

Fibromuscular dysplasia (FMD) is a non-inflammatory vascular disease that is characterized by unexplained systemic hypertension occurring in young people, associated with arterial stenosis, aneurysm rupture, intracranial/renal infarction, and stroke. Although the gold standard for the diagnosis remains catheter-angiography, biological markers would be helpful due to the delay from first symptom to diagnosis. Adenosine is an ATP derivative, that may be implicated in FMD pathophysiology. We hypothesized that changes in adenosine blood level (ABL) and production of adenosine receptors may be associated with FMD. Using peripheral blood mononuclear cells, we evaluated A1, A2A, and A2B receptor production by Western blot, in 67 patients (17 men and 50 women, mean (range) age 55 (29–77) years and 40 controls, 10 men and 30 women, mean (range) age 56 (37–70)). ABL was evaluated by liquid chromatography, mass spectrometry. ABL was significantly higher in patients vs. controls, mean (range): 1.7 (0.7–3) µmol/L vs. controls 0.6 (0.4–0.8) µmol/L (+180%) p < 0.001. While A1R and A2AR production did not differ in patients and controls, we found an over-production of A2BR in patients: 1.70 (0.90–2.40; arbitrary units) vs. controls = 1.03 (0.70–1.40), mean + 65% (p < 0.001). A2BR production with a cut off of 1.3 arbitrary units, gives a good sensitivity and specificity for the diagnosis. Production measurement of A2BR on monocytes and ABL could help in the diagnosis, especially in atypical or with poor symptoms.
Keywords: adenosine; A2B adenosine receptors; fibromuscular dysplasia adenosine; A2B adenosine receptors; fibromuscular dysplasia

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MDPI and ACS Style

Guiol, C.; El Harake, S.; Fromonot, J.; Chefrour, M.; Gastaldi, M.; Alibouch, Y.; Doublier, M.; Deharo, P.; Sarlon, G.; Marlinge, M.; et al. Adenosine Receptors Profile in Fibromuscular Dysplasia. Biomedicines 2022, 10, 2831. https://doi.org/10.3390/biomedicines10112831

AMA Style

Guiol C, El Harake S, Fromonot J, Chefrour M, Gastaldi M, Alibouch Y, Doublier M, Deharo P, Sarlon G, Marlinge M, et al. Adenosine Receptors Profile in Fibromuscular Dysplasia. Biomedicines. 2022; 10(11):2831. https://doi.org/10.3390/biomedicines10112831

Chicago/Turabian Style

Guiol, Claire, Sarah El Harake, Julien Fromonot, Mohamed Chefrour, Marguerite Gastaldi, Yassine Alibouch, Maxime Doublier, Pierre Deharo, Gabrielle Sarlon, Marion Marlinge, and et al. 2022. "Adenosine Receptors Profile in Fibromuscular Dysplasia" Biomedicines 10, no. 11: 2831. https://doi.org/10.3390/biomedicines10112831

APA Style

Guiol, C., El Harake, S., Fromonot, J., Chefrour, M., Gastaldi, M., Alibouch, Y., Doublier, M., Deharo, P., Sarlon, G., Marlinge, M., Lalevee, N., Guieu, R., & Silhol, F. (2022). Adenosine Receptors Profile in Fibromuscular Dysplasia. Biomedicines, 10(11), 2831. https://doi.org/10.3390/biomedicines10112831

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