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Biomedicines
Volume 10
Issue 11
10.3390/biomedicines10112745
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Review
Peer-Review Record

Synaptic Plasticity in the Pain-Related Cingulate and Insular Cortex

Biomedicines 2022, 10(11), 2745; https://doi.org/10.3390/biomedicines10112745
by Jung-Hyun Alex Lee 1, Qiyu Chen 2,3 and Min Zhuo 1,2,4,*
Reviewer 1: Anonymous
Reviewer 2:
Giuseppe Sciamanna
Reviewer 3: Anonymous
Biomedicines 2022, 10(11), 2745; https://doi.org/10.3390/biomedicines10112745
Submission received: 20 September 2022 / Revised: 14 October 2022 / Accepted: 22 October 2022 / Published: 28 October 2022
(This article belongs to the Special Issue Molecular Mechanisms of Chronic Pain and New Therapeutic Strategies)

Round 1

Reviewer 1 Report

This review of plasticity in the cingulate and insular cortices related to pain is well written and informative. It provides a solid background for people unfamiliar with the field. 

Author Response

Dear Reviewer,

Thank you for your kind comments regarding this review paper.

Regards,
Jung-Hyun Lee

Reviewer 2 Report

Paper by Jung-Hyun and coworkers report a clear overview over synaptic plasticity in pain related are such as  cingulate and insular cortex. Paper is clear and well written. Authors completely describe the main research in human and animal models as well as the cellular mechanism underlying the LTP and LTD phenomenon. I would appreciate if authors can include in the description of neuromodulation of ACC plasticity, also the dopaminergic signaling, that have been proved to have massive impact in other brain regions as basal ganglia.

Author Response

Dear Reviewer,

Thank you for your comments and suggestions. An additional paragraph has been added to the neuromodulation section to include the role of dopaminergic signaling in neuromodulation of ACC plasticity.

Kind regards,
Jung-Hyun Lee

Reviewer 3 Report

The review focus is on plasticity mechanisms in the ACC and IC that are related to central pain perception.

The topic is interesting and the paper is well written and clear. I only have few suggestions that I hope will help the Authors.

Given that the manuscript will mainly encounter the interest of neuroscientist, some part may results redundant. For example the introduction to synaptic transmission in paragraph 4 should be eliminated or shortened , presenting only the specific evidence for ACC and IC.

Same as above for the beginning of paragraph 6 when describing early and late –LTP.

In my opinion Reference 79 is not appropriate and should be eliminated.

Also paragraph 12 should be eliminated or  shortened and integrated in the part related to LTP and LTD.

Author Response

Dear Reviewer,

Thank you for your comments and suggestions. The following revisions have been made.

The introduction to synaptic transmission has been shortened.

The introduction to early and late-LTP has been shortened.

Reference 79 and the related content has been removed.

Section 12 has been shortened and placed after the sections regarding LTP and LTD.

Kind regards,
Jung-Hyun Lee

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