Is Restless Legs Syndrome De Facto Thyroid Disease?
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. Characteristics of the Study Group
3.2. Characteristics and Epidemiology of Restless Legs Syndrome
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Subgroup (N) | Sex (Female vs. Male) | Average Age in Years (±SD) | Average BMI in kg/m2 (±SD) |
---|---|---|---|
A1 (32) | 81.3% (26) vs. 18.7% (6) | 40.5 ± 10.2 | 29.9 ± 7.1 |
B1 (45) | 71.1% (32) vs. 28.9% (13) | 38.6 ± 12.8 | 27.6 ± 3.4 |
C1 (33) | 87.9% (29) vs. 12.1% (4) | 39.3 ± 13.1 | 25.7 ± 5.5 |
C2 (33) | 93.9% (31) vs. 6.1% (2) | 39.5 ± 12.3 | 25.7 ± 5.7 |
C3 (32) | 90.6% (29) vs. 9.4% (3) | 36.6 ± 14.4 | 28.3 ± 7.4 |
D (62) | 41.9% (26) vs. 58.1% (36) | 35.2 ± 14.0 | 25.8 ± 5.7 |
Parameter | C1 vs. C2 (p Value) | C1 vs. C3 (p Value) | C2 vs. C3 (p Value) |
---|---|---|---|
RBC [×106/μL] | ns (p = 0.991) | 4.5 ± 0.3 vs. 4.3 ± 0.3 (p = 0.016) | 4.5 ± 0.5 vs. 4.3 ± 0.3 (p = 0.049) |
Hematocrit [%] | ns (p = 0.676) | 39.8 ± 3.0 vs. 38.1 ± 2.5 (p = 0.048) | 40.1 ± 3.3 vs. 38.1 ± 2.5 (p = 0.030) |
PLT [x 103/μL] | ns (p = 0.276) | 274.3 ± 63.34 vs. 236.2 ± 52.5 (p = 0.042) | ns (p = 0.278) |
RDW-CV [%] | ns (p = 0.836) | 12.8 ± 0.7 vs. 12.3 ± 0.7 (p = 0.040) | 12.9 ± 0.7 vs. 12.3 ± 0.7 (p = 0.015) |
serum sodium [mmol/L] | ns (p = 0.444) | 143.1 ± 1.1 vs. 141.6 ± 0.7 (p = 0.028) | ns (p = 0.269) |
TSH [uIU/mL] | 1.5 ± 0.7 vs. 2.1 ± 1.2 (p = 0.018) | ns (p = 0.729) | ns (p = 0.090) |
Subgroup (N) | Average Thyroid Volume in cm3 (±SD) |
---|---|
A1 | 12.0 ± 2.1 |
B1 | 14.3 ± 6.0 |
C1 | 16.4 ± 4.5 |
C2 | 9.3 ± 4.8 |
C3 | 18.9 ± 9.8 |
D | 17.6 ± 6.5 |
Parameter | Patients with RLS | Patients without RLS | p Value |
---|---|---|---|
Group A | |||
thyroid volume [cm3] | 6.1 ± 4.1 | 10.8 ± 4.1 | 0.008 |
MCHC [g/dL] | 34.4 ± 0.3 | 33.8 ± 0.8 | 0.035 |
ALT [U/L] | 18.9 ± 8.1 | 13.9 ± 5.4 | 0.041 |
Group B | |||
creatinine [mg/dL] | 0.9 ± 0.1 | 0.7 ± 0.2 | 0.002 |
fT3 [pg/mL] | 2.8 ± 0.2 | 3.3 ± 0.3 | 0.004 |
Group C | |||
ALT [U/L] | 18.2 ± 8.8 | 14.4 ± 4.3 | 0.011 |
AST [U/L] | 25.1 ± 16.9 | 19.5 ± 5.0 | 0.021 |
calcium [mmol/L] | 2.3 ± 0.1 | 2.2 ± 0.1 | 0.003 |
ferritin [μg/dL] | 35.6 ± 26.7 | 62.2 ± 49.6 | 0.022 |
fT3 [pg/mL] | 2.9 ± 0.4 | 3.1 ± 0.3 | 0.009 |
Group D | |||
thyroid volume [cm3] | 13.18 ± 4.44 | 18.73 ± 6.37 | 0.026 |
MCV [fl] | 85.00 ± 3.37 | 88.38 ± 2.83 | 0.006 |
MCHC [pg] | 28.48 ± 1.48 | 29.81 ± 0.97 | 0.004 |
PDW [fl] | 14.25 ± 1.36 | 12.53 ± 2.10 | 0.036 |
magnesium [mmol/L] | 0.69 ± 0.02 | 0.76 ± 0.04 | 0.002 |
Parameter | Patients with RLS | Patients without RLS | p Value |
---|---|---|---|
Subgroup A1 | |||
ferritin [μg/dL] | 35.4 ± 28.4 | 60.9 ± 50.8 | 0.026 |
Subgroup B1 | |||
MCV [fl] | 86.5 ± 3.4 | 88.9 ± 3.9 | 0.023 |
fT3 [pg/mL] | 2.7 ± 0.3 | 3.2 ± 0.2 | 0.004 |
Subgroup C1 | |||
PDW [fl] | 11.9 ± 1.2 | 13.3 ± 1.7 | 0.045 |
MPV [fl] | 11.0 ± 0.8 | 10.2 ± 0.2 | 0.021 |
P-LCR [%] | 27.1 ± 3.9 | 33.3 ± 6.3 | 0.019 |
calcium [mmol/L] | 2.3 ± 0.1 | 2.2 ± 0.1 | 0.001 |
Subgroup C2 | |||
thyroid volume [cm3] | 6.1 ± 4.1 | 10.5 ± 4.5 | 0.022 |
MCHC [g/dL] | 34.4 ± 0.3 | 33.8 ± 0.8 | 0.030 |
Subgroup C3 | |||
creatinine [mg/dL] | 0.8 ± 0.1 | 0.6 ± 0.2 | 0.002 |
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Suwała, S.; Rzeszuto, J.; Glonek, R.; Krintus, M.; Junik, R. Is Restless Legs Syndrome De Facto Thyroid Disease? Biomedicines 2022, 10, 2502. https://doi.org/10.3390/biomedicines10102502
Suwała S, Rzeszuto J, Glonek R, Krintus M, Junik R. Is Restless Legs Syndrome De Facto Thyroid Disease? Biomedicines. 2022; 10(10):2502. https://doi.org/10.3390/biomedicines10102502
Chicago/Turabian StyleSuwała, Szymon, Jakub Rzeszuto, Rafał Glonek, Magdalena Krintus, and Roman Junik. 2022. "Is Restless Legs Syndrome De Facto Thyroid Disease?" Biomedicines 10, no. 10: 2502. https://doi.org/10.3390/biomedicines10102502