Long-Term Outcome of Leptospirosis Infection with Acute Kidney Injury
and Chih-Wei Yang 1,*
Round 1
Reviewer 1 Report
- In the introduction part- the authors haven’t described thoroughly the pathophisiological mechanism of AKI in leptospirosis and CKD in silent leptospirosis and in those with AKI. Also, the authors haven’t mentioned which other organs are affected by leptospirosis.
- In the results part, the authors need to provide more explanation related to the models they have choosen (model 1, model 2).
- the discussions part need to be improve- the authors need to compare their results with other studies.
- The conclusions part need also to be improved- is to short and doesnt offer enough information for a conclusions part. The authors need to write why this study is important for practioners and for literature.
Author Response
Please see the attachment.
Author Response File: Authors' reply.pdf
Reviewer 2 Report
Interesting study on infection-related AKI.
Nevertheless, that a lack of association between the risk of AKI and chronic co-morbidities was shown (table 1), the reader (not familiar with leptospirosis cases) will appreciate some more data on acute risk factors of AKI (especially severe AKI) identified among patients infected with Leptospira.
Specific questions:
- Was the time from the infection diagnosis to referral to the hospital and to presenting AKI - longer, than in patients with no AKI?
- What was specific treatment (if any) for infection-related TIN (tubular-intestistial nephritis) ?
- Any steroids?
- Any differences in treatment protocol between AKI/AKI-RRT/non-AKI patients?
- Is the common protocol of management universal in all medical centers, or is locally different?
Author Response
Please see the attachment.
Author Response File: Author's reply file.pdf
Round 2
Reviewer 1 Report
I dont have anything to add.
Author Response
Thank you for your suggestion.
Reviewer 2 Report
The revised manuscript responses to the previous comment
Author Response
Thank you for your suggestion.
