Next Article in Journal
Macrophages Modulate Hepatic Injury Involving NLRP3 Inflammasome: The Example of Efavirenz
Previous Article in Journal
Non-Integrating Lentiviral Vectors in Clinical Applications: A Glance Through
Review

Targeting Endoplasmic Reticulum Stress as an Effective Treatment for Alcoholic Pancreatitis

by 1, 1 and 1,2,*
1
Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
2
Iowa City VA Health Care System, Iowa City, IA 52246, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Shaker A. Mousa
Biomedicines 2022, 10(1), 108; https://doi.org/10.3390/biomedicines10010108
Received: 19 November 2021 / Revised: 28 December 2021 / Accepted: 30 December 2021 / Published: 5 January 2022
(This article belongs to the Section Cell Biology and Pathology)
Pancreatitis and alcoholic pancreatitis are serious health concerns with an urgent need for effective treatment strategies. Alcohol is a known etiological factor for pancreatitis, including acute pancreatitis (AP) and chronic pancreatitis (CP). Excessive alcohol consumption induces many pathological stress responses; of particular note is endoplasmic reticulum (ER) stress and adaptive unfolded protein response (UPR). ER stress results from the accumulation of unfolded/misfolded protein in the ER and is implicated in the pathogenesis of alcoholic pancreatitis. Here, we summarize the possible mechanisms by which ER stress contributes to alcoholic pancreatitis. We also discuss potential approaches targeting ER stress and UPR in developing novel therapeutic strategies for the disease. View Full-Text
Keywords: alcohol abuse; cell signaling; FDA-approved drugs; oxidative stress; therapy alcohol abuse; cell signaling; FDA-approved drugs; oxidative stress; therapy
Show Figures

Figure 1

MDPI and ACS Style

Li, H.; Wen, W.; Luo, J. Targeting Endoplasmic Reticulum Stress as an Effective Treatment for Alcoholic Pancreatitis. Biomedicines 2022, 10, 108. https://doi.org/10.3390/biomedicines10010108

AMA Style

Li H, Wen W, Luo J. Targeting Endoplasmic Reticulum Stress as an Effective Treatment for Alcoholic Pancreatitis. Biomedicines. 2022; 10(1):108. https://doi.org/10.3390/biomedicines10010108

Chicago/Turabian Style

Li, Hui, Wen Wen, and Jia Luo. 2022. "Targeting Endoplasmic Reticulum Stress as an Effective Treatment for Alcoholic Pancreatitis" Biomedicines 10, no. 1: 108. https://doi.org/10.3390/biomedicines10010108

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop