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Decoding the Pluripotency Network: The Emergence of New Transcription Factors

by Kai Chuen Lee 1, Wing Ki Wong 1 and Bo Feng 1,2,*
1
Key Laboratory for Regenerative Medicine, Ministry of Education, School of Biomedical Sciences, Faculty of Medicine, the Chinese University of Hong Kong, Room 105A, 1/F, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, Shatin, N.T., Hong Kong, China
2
SBS Core Laboratory, Shenzhen Research Institute, the Chinese University of Hong Kong, 4/F CUHK Shenzhen Research Institute Building, No.10, 2nd Yuexing Road, Nanshan District, Shenzhen 518057, China
*
Author to whom correspondence should be addressed.
Biomedicines 2013, 1(1), 49-78; https://doi.org/10.3390/biomedicines1010049
Received: 23 October 2013 / Revised: 10 December 2013 / Accepted: 11 December 2013 / Published: 16 December 2013
(This article belongs to the Special Issue Feature Papers)
Since the successful isolation of mouse and human embryonic stem cells (ESCs) in the past decades, massive investigations have been conducted to dissect the pluripotency network that governs the ability of these cells to differentiate into all cell types. Beside the core Oct4-Sox2-Nanog circuitry, accumulating regulators, including transcription factors, epigenetic modifiers, microRNA and signaling molecules have also been found to play important roles in preserving pluripotency. Among the various regulations that orchestrate the cellular pluripotency program, transcriptional regulation is situated in the central position and appears to be dominant over other regulatory controls. In this review, we would like to summarize the recent advancements in the accumulating findings of new transcription factors that play a critical role in controlling both pluripotency network and ESC identity. View Full-Text
Keywords: pluripotency; embryonic stem cell; transcriptional network; transcription factor pluripotency; embryonic stem cell; transcriptional network; transcription factor
MDPI and ACS Style

Lee, K.C.; Wong, W.K.; Feng, B. Decoding the Pluripotency Network: The Emergence of New Transcription Factors. Biomedicines 2013, 1, 49-78.

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