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Article

Tumor Characteristic Variations between Symptomatic and Asymptomatic Endometrial Cancer

1
Department of Gynecology and Obstetrics, University Hospital Brno, Masaryk University, 60177 Brno, Czech Republic
2
Department of Internal Medicine, Hematology and Oncology, University Hospital Brno, Masaryk University, 60177 Brno, Czech Republic
3
Department of Pathology, University Hospital Brno, Masaryk University, 60177 Brno, Czech Republic
4
Faculty of Medicine, Institute of Biostatistics and Analyses, Masaryk University, 60177 Brno, Czech Republic
*
Author to whom correspondence should be addressed.
Academic Editor: Stefano Restaino
Healthcare 2021, 9(7), 902; https://doi.org/10.3390/healthcare9070902
Received: 20 May 2021 / Revised: 13 July 2021 / Accepted: 14 July 2021 / Published: 16 July 2021
(This article belongs to the Special Issue Diagnosis and Treatment for Women's Health)
Endometrial cancer is the most common gynecologic malignancy in Europe and usually diagnosed in its initial stage owing to early symptoms of abnormal bleeding. There is no population screening for this disease, although it can sometimes be accidentally diagnosed in asymptomatic patients. Our study aims to determine differences in clinical and tumor characteristics between an asymptomatic and symptomatic group of patients. This unicentric prospective observational study took place in University Hospital Brno between January 2016 and December 2019. A total of 264 patients met inclusion criteria (26% asymptomatic, 74% with reported symptoms). We did not find a statistically significant difference in clinical characteristics (menopausal status, parity, age, BMI, and serum level of CA 125) between groups. According to ultrasound examination, bleeding tumors were larger (19.5 vs. 12.7 mm, p ≤ 0.001). Definitive histology results indicated more frequent lymphovascular space invasion (p < 0.001), along with deep myometrial (p = 0.001) and cervical (p = 0.002) invasion. There was no difference in advanced stages of the tumor. We did not substantiate statistically significant difference in immunohistochemical profile (estrogen and progesterone receptors, L1 cell adhesion molecule, tumor protein p53), which is relevant for tumor recurrence risk and survival capacity. Our conclusions affirmed that bleeding occurs more often among patients with local tumor invasion into the myometrium and cervical stroma. Final International Federation of Gynecology and Obstetrics (FIGO) stage, histology, and immunohistochemical characteristics do not significantly affect symptom appearance. View Full-Text
Keywords: endometrial cancer; tumor markers; ER; PR; p53; L1CAM endometrial cancer; tumor markers; ER; PR; p53; L1CAM
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MDPI and ACS Style

Vinklerová, P.; Bednaříková, M.; Minář, L.; Felsinger, M.; Hausnerová, J.; Ovesná, P.; Weinberger, V. Tumor Characteristic Variations between Symptomatic and Asymptomatic Endometrial Cancer. Healthcare 2021, 9, 902. https://doi.org/10.3390/healthcare9070902

AMA Style

Vinklerová P, Bednaříková M, Minář L, Felsinger M, Hausnerová J, Ovesná P, Weinberger V. Tumor Characteristic Variations between Symptomatic and Asymptomatic Endometrial Cancer. Healthcare. 2021; 9(7):902. https://doi.org/10.3390/healthcare9070902

Chicago/Turabian Style

Vinklerová, Petra, Markéta Bednaříková, Luboš Minář, Michal Felsinger, Jitka Hausnerová, Petra Ovesná, and Vít Weinberger. 2021. "Tumor Characteristic Variations between Symptomatic and Asymptomatic Endometrial Cancer" Healthcare 9, no. 7: 902. https://doi.org/10.3390/healthcare9070902

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