Similar Quality of Life and Safety in Patients Receiving Inpatient or Outpatient Chemotherapy: A Focus on Esophageal Squamous Cell Carcinoma
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patient Selection
2.2. Quality of Life Assessment
2.3. Chemotherapy
2.4. Statistics
2.5. Statement of Ethics
3. Results
3.1. Patient Characteristics
3.2. QLQ-C30
3.3. QLQ-OES18
3.4. AEs of Chemotherapy
4. Discussion
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Characteristics | Inpatient Chemotherapy Group (N = 53) | Outpatient Chemotherapy Group (N = 54) | p-Value |
---|---|---|---|
Body height (cm) (median, range) | 167.3(154.1–175.6) | 165.5 (142.6.1–180.3) | |
Body weight (kg) (median, range) | 58.5 (39.8–77.5) | 58.2 (40.8–94.3) | |
Age (years) | |||
<60 years | 39 (73.6%) | 30 (55.6%) | 0.05 |
≥60 years | 14 (26.4%) | 24 (44.4%) | |
Sex | |||
Male | 52 (98.1%) | 50 (92.6%) | 0.18 |
Female | 1 (1.9%) | 4 (7.4%) | |
Tobacco smoking | |||
Yes | 49 (92.5%) | 48 (88.9%) | 0.53 |
No | 4 (7.5%) | 6 (11.1%) | |
Alcohol consumption | |||
Yes | 49 (92.5%) | 50 (92.6%) | 0.98 |
No | 4 (7.5%) | 4 (7.4%) | |
Betel nut chewing | |||
Yes | 40 (75.5%) | 40 (74.1%) | 0.87 |
No | 13 (24.5%) | 14 (25.9%) | |
Tumor stage | |||
II | 8 (15.1%) | 9 (16.7%) | 0.96 |
III | 22 (41.5%) | 22 (40.7%) | |
IV | 23 (43.4%) | 23 (42.6%) |
Characteristics | Inpatient Chemotherapy Group (N = 53) Median (range) | Outpatient Chemotherapy Group (N = 54) Median (range) | p-Value |
---|---|---|---|
Global health status | |||
Global health status/quality of life | 50 (0–100) | 54 (0–100) | 0.53 |
Functional scales | |||
Physical functioning | 87 (73–100) | 93 (73–100) | 0.27 |
Role functioning | 83 (33–100) | 100 (33–100) | 0.09 |
Emotional functioning | 83 (8–100) | 96 (25–100) | 0.05 |
Cognitive functioning | 83 (33–100) | 83 (33–100) | 0.38 |
Social functioning | 100 (0–100) | 100 (33–100) | 0.12 |
Symptom scales | |||
Fatigue | 33 (0–100) | 22 (0–100) | 0.08 |
Nausea and vomiting | 17 (0–67) | 0 (0–100) | 0.71 |
Pain | 8 (0–83) | 17 (0–83) | 0.64 |
Symptom items | |||
Dyspnea | 0 (0–100) | 0 (0–100) | 0.34 |
Insomnia | 33 (0–67) | 33 (0–100) | 0.76 |
Appetite loss | 33 (0–100) | 33 (0–100) | 0.17 |
Constipation | 33 (0–67) | 33 (0–100) | 0.73 |
Diarrhea | 0 (0–67) | 0 (0–67) | 0.08 |
Financial difficulties | 33 (0–100) | 0 (0–100) | 0.17 |
Characteristics | Inpatient Chemotherapy Group (N = 53) Median (range) | Outpatient Chemotherapy Group (N = 54) Median (range) | p-Value |
---|---|---|---|
Symptom scales | |||
Eating | 25 (0–83) | 8 (0–67) | 0.07 |
Reflux | 17 (0–83) | 0 (0–67) | 0.09 |
Pain | 11 (0–89) | 11 (0–67) | 0.25 |
Trouble swallowing saliva (OESSV) | 33 (0–100) | 0 (0–100) | 0.99 |
Choking when swallowing (OESCH) | 0 (0–100) | 0 (0–100) | 0.99 |
Dry mouth (OESDM) | 33 (0–100) | 0 (0–100) | 0.06 |
Trouble with taste (OESTA) | 0 (0–100) | 0 (0–100) | 0.65 |
Trouble with coughing (OESCO) | 33 (0–100) | 33 (0–100) | 0.97 |
Trouble talking (OESSP) | 0 (0–100) | 0 (0–100) | 0.27 |
Functional scales | |||
Dysphagia | 44 (0–100) | 33 (0–100) | 0.99 |
Characteristics | Inpatient Chemotherapy Group (N = 53) | Outpatient Chemotherapy Group (N = 54) | p-Value |
---|---|---|---|
Nausea | |||
Grade 0 | 43 (81.1%) | 43 (79.6%) | 0.80 |
Grade 1 | 7 (13.2%) | 9 (16.7%) | |
Grade 2 | 3 (5.7%) | 2 (3.7%) | |
Vomiting | |||
Grade 0 | 49 (92.4%) | 50 (92.6%) | 0.56 |
Grade 1 | 3 (5.7%) | 4 (7.4%) | |
Grade 2 | 1 (1.9%) | 0 (0%) | |
Mucositis | |||
Grade 0 | 45 (85.0%) | 47 (87.0%) | 0.67 |
Grade 1 | 4 (7.5%) | 2 (3.7%) | |
Grade 2 | 4 (7.5%) | 5 (9.3%) | |
Diarrhea | |||
Grade 0 | 45 (85.0%) | 49 (90.7%) | 0.29 |
Grade 1 | 8 (15.0%) | 4 (7.4%) | |
Grade 2 | 0 (0%) | 1 (1.9%) | |
Constipation | |||
Grade 0 | 30 (56.6%) | 28 (51.9%) | 0.25 |
Grade 1 | 11 (20.8%) | 18 (33.3%) | |
Grade 2 | 12 (22.6%) | 7 (12.9%) | |
Grade 3 | 0 (0%) | 1 (1.9%) | |
Neutropenia | |||
Grade 0 | 26 (49.1%) | 26 (48.1%) | 0.61 |
Grade 1 | 27 (50.9%) | 27 (50.0%) | |
Grade 2 | 0 (0%) | 1 (1.9%) | |
Anemia | |||
Grade 0 | 19 (35.8%) | 19 (35.2%) | 0.70 |
Grade 1 | 22 (41.5%) | 21 (38.9%) | |
Grade 2 | 11 (20.8%) | 13 (24.1%) | |
Grade 3 | 1 (1.9%) | 0 (0%) | |
Grade 4 | 0 (0%) | 1 (1.8%) | |
Thrombocytopenia | |||
Grade 0 | 36 (67.9%) | 37 (68.5%) | 0.99 |
Grade 1 | 16 (30.2%) | 16 (29.6%) | |
Grade 2 | 1 (1.9%) | 1 (1.9%) | |
Nephrotoxicity | |||
Grade 0 | 27 (50.9%) | 23 (42.6%) | 0.75 |
Grade 1 | 16 (28.3%) | 19 (35.2%) | |
Grade 2 | 7 (15.1%) | 10 (18.5%) | |
Grade 3 | 3 (5.7%) | 2 (3.7%) |
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Chen, Y.-H.; Chen, S.-W.; Lu, H.-I.; Lo, C.-M.; Li, S.-H. Similar Quality of Life and Safety in Patients Receiving Inpatient or Outpatient Chemotherapy: A Focus on Esophageal Squamous Cell Carcinoma. Healthcare 2020, 8, 447. https://doi.org/10.3390/healthcare8040447
Chen Y-H, Chen S-W, Lu H-I, Lo C-M, Li S-H. Similar Quality of Life and Safety in Patients Receiving Inpatient or Outpatient Chemotherapy: A Focus on Esophageal Squamous Cell Carcinoma. Healthcare. 2020; 8(4):447. https://doi.org/10.3390/healthcare8040447
Chicago/Turabian StyleChen, Yen-Hao, Su-Wei Chen, Hung-I Lu, Chien-Ming Lo, and Shau-Hsuan Li. 2020. "Similar Quality of Life and Safety in Patients Receiving Inpatient or Outpatient Chemotherapy: A Focus on Esophageal Squamous Cell Carcinoma" Healthcare 8, no. 4: 447. https://doi.org/10.3390/healthcare8040447