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Education and Protein Supplementation Improve Nutritional Biomarkers among Hypoalbuminemic Peritoneal Dialysis Patients: A Quasi-Experimental Design

1
School of Nutrition and Health Sciences, Taipei Medical University, Taipei 110, Taiwan
2
Department of Nutrition Therapy, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi 622, Taiwan
3
Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung City 402, Taiwan
4
Department of Nephrology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taipei 231, Taiwan
5
Department of Nutrition, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taipei 231, Taiwan
6
Department of Nutrition, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 111, Taiwan
7
Department of Nephrology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 111, Taiwan
8
Research Center of Geriatric Nutrition, Taipei Medical University, Taipei 110, Taiwan
9
Nutrition Research Center, Taipei Medical University Hospital, Taipei 110, Taiwan
*
Author to whom correspondence should be addressed.
Authors contributed equally to this paper.
Healthcare 2019, 7(4), 135; https://doi.org/10.3390/healthcare7040135
Received: 27 September 2019 / Revised: 31 October 2019 / Accepted: 4 November 2019 / Published: 5 November 2019
Protein-energy wasting is prevalent in peritoneal dialysis patients, which causes a heavy burden for individuals and healthcare systems. We aimed to investigate the effect of nutritional education, and/or protein supplementation on nutritional biomarkers in hypoalbuminemic peritoneal dialysis patients. A quasi-experimental study was conducted in two dialysis centers at Taipei Tzu Chi Hospital and Shin Kong Wu Ho-Su Memorial Hospital. Patients were allocated in three groups including control (n = 12), milk protein (n = 21) and soy protein (n = 20). All patients received dietary guidelines from dietitians and completed 3-day dietary records during monthly visits for consecutive three months. Nutrients were analyzed using Nutritionist Professional software. Blood urea nitrogen (BUN), creatinine, albumin, total protein, hemoglobin, serum calcium, phosphorus, sodium, and potassium were assessed monthly. Total cholesterol and triglycerides were measured every three months. After three-month intervention, protein intake (percent of total calories), and serum albumin were significantly increased in three groups. Protein, phosphorus intake, and BUN were increased in two intervention groups. Total serum protein increased in control and milk protein groups, and creatinine increased the control group. Serum phosphorus was not significantly changed. Nutritional education alone, or combined with protein supplementation, significantly improve protein intake, and nutritional status by increasing serum albumin, but not serum phosphorus in hypoalbuminemic peritoneal dialysis patients. View Full-Text
Keywords: nutritional education; protein supplements; milk protein; soy protein; peritoneal dialysis; biomarkers; hypoalbuminemia; serum albumin; serum phosphorus; experimental study nutritional education; protein supplements; milk protein; soy protein; peritoneal dialysis; biomarkers; hypoalbuminemia; serum albumin; serum phosphorus; experimental study
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Duong, T.V.; Tsao, C.-A.; Yang, E.; Peng, C.-H.; Hou, Y.-C.; Su, Y.-C.; Chang, J.-T.; Yang, S.-H. Education and Protein Supplementation Improve Nutritional Biomarkers among Hypoalbuminemic Peritoneal Dialysis Patients: A Quasi-Experimental Design. Healthcare 2019, 7, 135.

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